Li Kang, Liu Meiliang, Li Jianjun, Dong Aaobo, Zhou Yuxi, Ding Yibo, Liang Yanling, Shao Yiming
Guangxi Key Laboratory of AIDS Prevention and Treatment and Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University, Nanning, China.
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
AIDS Res Hum Retroviruses. 2019 Oct;35(10):972-977. doi: 10.1089/AID.2019.0149. Epub 2019 Jul 16.
We report here a novel HIV-1 recombinant form (18GXD4705) composed of CRF01_AE and subtype B, acquired from an unmarried HIV-positive young man subject infected through homosexual contact in Guangxi Province of eastern China. The phylogenetic analysis of the near full-length genome of 18GXD4705 indicated that one subtype B segment was inserted into the CRF01_AE backbone, with one recombinant breakpoint demonstrated in the pol region. The CRF01_AE region (I and III) of recombinant correlated with a previously reported subcluster 4 lineage. The B subregions (II) are greatly clustered together, with B strain references. The continued generation of this novel recombinant increases the genetic complexity and diversity of the HIV epidemic in Guangxi. In addition, further molecular epidemiological investigations should be conducted to continuously monitor the dynamic transmission of HIV-1 in the region.
我们在此报告一种新型的HIV-1重组形式（18GXD4705），它由CRF01_AE和B亚型组成，源自中国东部广西一名通过同性接触感染的未婚HIV阳性青年男性。对18GXD4705近全长基因组的系统发育分析表明，一个B亚型片段插入到CRF01_AE主干中，在pol区域显示有一个重组断点。重组体的CRF01_AE区域（I和III）与先前报道的亚簇4谱系相关。B子区域（II）与B株参考序列高度聚集在一起。这种新型重组体的持续产生增加了广西HIV流行的遗传复杂性和多样性。此外，应开展进一步的分子流行病学调查，以持续监测该地区HIV-1的动态传播。
