Department of Ultrasound Diagnosis, China Meitan General Hospital, Chaoyang District, Beijing, P.R. China.
Eur Rev Med Pharmacol Sci. 2018 Sep;22(17):5539-5545. doi: 10.26355/eurrev_201809_15815.
This study aims to investigate the correlations between the expression of human epidermal growth factor receptor 2 (C-erB-2), CD34, and estrogen receptor (ER) in breast cancer (BC) patients, and the signs of conventional ultrasonography and ultrasound elastography.
Clinical data of 88 patients who were pathologically diagnosed as breast cancer were retrospectively analyzed. HI VISION Avius color ultrasound device was used to perform ultrasound and related ultrasound parameters were analyzed. Expressions of C-erB-2, CD34, and ER were detected by immunohistochemistry.
There was a correlation between positive expression of C-erB-2 and the blood supply, lymph node metastasis and microcalcification in patients (p < 0.05). Patients were divided into high expression group and low expression group according to the median expression level of CD34. Expression of CD34 was correlated with the ultrasound sign of lymph node metastasis (p < 0.05). Positive expression of ER was correlated with the morphology, margin, and perimeter of the tumor (p < 0.05). Expression levels of C-erB-2, CD34, and ER were found to be increased in BC patients.
Combination of upregulated expression of C-erB-2, CD34, and ER and signs of ultrasound can improve the diagnosis of BC.
本研究旨在探讨乳腺癌患者人表皮生长因子受体 2（C-erB-2）、CD34 和雌激素受体（ER）的表达与常规超声及超声弹性成像征象的相关性。
回顾性分析 88 例经病理诊断为乳腺癌患者的临床资料，应用 HI VISION Avius 彩色超声诊断仪进行超声检查并分析相关超声参数，采用免疫组化法检测 C-erB-2、CD34 和 ER 的表达。
C-erB-2 阳性表达与患者的血供、淋巴结转移和微钙化有关（p<0.05）。根据 CD34 的中位表达水平将患者分为高表达组和低表达组，CD34 的表达与淋巴结转移的超声征象有关（p<0.05）。ER 的阳性表达与肿瘤的形态、边界和周长有关（p<0.05）。乳腺癌患者 C-erB-2、CD34 和 ER 的表达水平升高。
联合上调 C-erB-2、CD34 和 ER 的表达及超声征象可提高乳腺癌的诊断效能。
