多囊卵巢综合征患者的临床和生化特征与生活质量之间的关系。
The relationship between clinical and biochemical characteristics and quality of life in patients with polycystic ovary syndrome.
机构信息
Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Clin Endocrinol (Oxf). 2019 Jan;90(1):129-137. doi: 10.1111/cen.13858. Epub 2018 Oct 17.
BACKGROUND AND OBJECTIVE
While has been well demonstrated that clinical characteristics of polycystic ovary syndrome (PCOS) are associated with an impaired quality of life (QoL) in patients, it is unclear that whether the biochemical aspects of PCOS can influence their QoL. We aimed to investigate the relationship between clinical and biochemical characteristics, and various domains of QoL in patients with PCOS.
DESIGN
A cross-sectional study.
PATIENTS AND MEASUREMENTS
We assessed the association between clinical and biochemical characteristics and QoL domains (psychosocial-emotional, fertility, sexual function, and obesity-menstrual) in a total of 211 women with PCOS using a specific health-related quality-of-life questionnaire for PCOS patients.
RESULTS
Our findings showed positive significant association of QoL with age, and its negative significant associations with BMI, hirsutism and infertility (P < 0.05). We also found a negative association between FAI and total QoL (r = -0.14; P = 0.042) and domains of hirsutism (r = -0.14; P = 0.045) and obesity-menstrual (r = -0.23; P = 0.001). DHEAS was positively associated with the sexual function aspect of QoL (r = 0.20; P = 0.043). There were no significant associations between QoL and other hormonal parameters including LH to FSH ratio and total testosterone (tT). Significant associations were found between triglycerides (TG), total cholesterol (TC), LDL and HDL cholesterol, and domain of obesity-menstrual of QoL. HOMA-IR was significantly related to all QoL domains except self-image and hirsutism.
CONCLUSION
Although biochemical markers can influence QoL in patients with PCOS, clinical manifestations of this syndrome such as obesity, infertility and hirsutism seem to play roles in worsening QoL, in particular for psychosocial domains. Hence, clinicians should regularly assess the clinical and psychosocial dimensions of PCOS as well as biochemical aspects.
背景与目的
虽然多囊卵巢综合征（PCOS）的临床特征与患者生活质量（QoL）受损之间的关系已得到充分证实，但 PCOS 的生化方面是否会影响其 QoL 尚不清楚。我们旨在研究 PCOS 患者的临床和生化特征与 QoL 各领域之间的关系。
设计
横断面研究。
患者和测量
我们使用专门的多囊卵巢综合征患者健康相关生活质量问卷，评估了 211 名 PCOS 患者的临床和生化特征与 QoL 各领域（心理社会情感、生育、性功能和肥胖-月经）之间的关系。
结果
我们的研究结果显示，QoL 与年龄呈正相关，与 BMI、多毛症和不孕呈负相关（P<0.05）。我们还发现 FAI 与总 QoL（r=-0.14；P=0.042）和多毛症（r=-0.14；P=0.045）和肥胖-月经（r=-0.23；P=0.001）各领域之间存在负相关。DHEAS 与 QoL 的性功能方面呈正相关（r=0.20；P=0.043）。QoL 与其他激素参数，包括 LH 与 FSH 比值和总睾酮（tT）之间没有显著相关性。QoL 的肥胖-月经领域与甘油三酯（TG）、总胆固醇（TC）、LDL 和 HDL 胆固醇之间存在显著相关性。HOMA-IR 与除自我形象和多毛症以外的所有 QoL 领域均相关。
结论
尽管生化标志物会影响 PCOS 患者的 QoL，但该综合征的临床表现，如肥胖、不孕和多毛症，似乎会导致 QoL 恶化，特别是在心理社会领域。因此，临床医生应定期评估 PCOS 的临床和心理社会维度以及生化方面。
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