Gamburg L Iu
Eksp Onkol. 1986;8(5):45-7.
Chloroquine was administered to 2-month hamsters inoculated at birth with an oncogenic virus SV-40 which was injected daily in a dose of 30 mg/kg for a month. Chloroquine-treated animals showed a statistically significant (6 weeks) shorter latent period of tumour development. The drug exerted no effect neither on the rate and incidence of transplantable E-1 test tumours or on the phenomenon of resistance in experiments on 4-6-month hamsters under its multiple administration in doses close to maximum tolerated ones (40 mg/kg).
给出生时接种致癌病毒SV - 40的2个月大仓鼠施用氯喹，病毒以30毫克/千克的剂量每日注射，持续一个月。经氯喹治疗的动物肿瘤发生的潜伏期在统计学上显著缩短（6周）。在对4 - 6个月大仓鼠进行的实验中，当以接近最大耐受剂量（40毫克/千克）多次给药时，该药物对可移植E - 1试验肿瘤的发生率和生长速度以及耐药现象均无影响。
