Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
BMJ Open. 2018 Sep 19;8(9):e020735. doi: 10.1136/bmjopen-2017-020735.
To investigate the association between bronchopulmonary dysplasia (BPD) and the risk of cerebral palsy (CP) in children.
We used EMBASE, PubMed and Web of Science to conduct a meta-analysis of studies published before 1 September 2017, written in English whose titles or abstracts discussed an association between BPD and CP.
Observational studies, for example, case-control and cohort studies were included.
All review stages were conducted by two reviewers independently. Data synthesis was undertaken via meta-analysis of available evidence.
The prevalence of developing CP was measured after exposure to BPD.
Among 1234 initially identified studies, we selected those that addressed an association between BPD and CP according to our preselected inclusion criteria. Our meta-analysis included 11 studies. According to a random effect model, BPD was significantly associated with CP (ORs 2.10; 95% CI 1.57 to 2.82) in preterm infants. Factors explaining differences in the study results included study design, the definition of BPD, the time of diagnosis of CP and whether the studies adjusted for potential confounders.
This study suggests that BPD is a risk factor for CP. Further studies are required to confirm these results and to detect the influence of variables across studies.
探讨支气管肺发育不良（BPD）与儿童脑瘫（CP）风险之间的关联。
我们使用 EMBASE、PubMed 和 Web of Science 对截至 2017 年 9 月 1 日之前发表的英文文献进行了荟萃分析，这些文献的标题或摘要讨论了 BPD 与 CP 之间的关联。
纳入观察性研究，例如病例对照和队列研究。
所有综述阶段均由两名评审员独立进行。通过对现有证据进行荟萃分析来进行数据综合。
在接触 BPD 后测量发生 CP 的流行率。
在最初确定的 1234 项研究中，我们根据预先选定的纳入标准选择了那些涉及 BPD 与 CP 之间关联的研究。我们的荟萃分析包括 11 项研究。根据随机效应模型，BPD 与早产儿 CP 显著相关（ORs 2.10；95%CI 1.57 至 2.82）。解释研究结果差异的因素包括研究设计、BPD 定义、CP 诊断时间以及研究是否调整了潜在混杂因素。
本研究表明 BPD 是 CP 的一个危险因素。需要进一步的研究来证实这些结果，并检测研究之间变量的影响。
