China Key Laboratory of Functional Molecular Engineering of Guangdong Province, Guangdong Engineering Research Center for Green Fine Chemicals, School of Chemistry and Chemical Engineering , South China University of Technology , Guangzhou 510641 , China.
Org Lett. 2018 Oct 5;20(19):6140-6143. doi: 10.1021/acs.orglett.8b02613. Epub 2018 Sep 20.
Zn(OAc)-catalyzed highly regioselective carbonylacetylation of indoles and pyrroles with α-diazoketones has been developed. This transformation involves a combination of Wolff rearrangement/cross-coupling relay and provides an efficient approach to versatile 3-carbonylacetylindoles and 2-carbonylacetylpyrroles with a broad range of functional group tolerance.
Zn(OAc)催化的吲哚和吡咯与α-重氮酮的高区域选择性羰基乙酰化反应已经被开发出来。这种转化涉及Wolff 重排/交叉偶联接力的组合，为具有广泛官能团容忍度的多功能 3-羰基乙酰吲哚和 2-羰基乙酰吡咯提供了一种有效的方法。
