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黑色素对金纳米颗粒诱导的大鼠肝毒性和脂质过氧化的影响。

Effect of melanin on gold nanoparticle-induced hepatotoxicity and lipid peroxidation in rats.

机构信息

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia,

Committee of Radiation and Environmental Pollution Protection (CREPP), Department of Physics, College of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

出版信息

Int J Nanomedicine. 2018 Sep 6;13:5207-5213. doi: 10.2147/IJN.S170758. eCollection 2018.

DOI:10.2147/IJN.S170758
PMID:30233181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6135214/
Abstract

INTRODUCTION

Melanin pigments are produced by melanocytes and are believed to act as antioxidants based on the belief that melanin can suppress electronically stirred states and scavenge the free radicals.

MATERIALS AND METHODS

The study was aimed to verify and prove the toxicity induced by administration of gold nanoparticles (GNPs) and to characterize the role of melanin as an antioxidant against inflammatory liver damage, oxidative stress, and lipid peroxidation induced intraperitoneally by GNPs in vivo.

RESULTS

The findings from this study confirmed that administration of GNPs intraperitoneally caused liver damage in addition to producing oxidative stress and fatty acid peroxidation. The treatment of rats with melanin along with GNPs induced dramatic changes in all the measured biochemical parameters. Our data demonstrated that melanin completely inhibited inflammatory liver damage, oxidative stress, and lipid peroxidation, which was confirmed by the histological investigation of different liver sections stained by H&E.

CONCLUSION

These results suggest the beneficial use of melanin together with GNPs for alleviating its toxicity. Other studies should be implemented taking into consideration the role of melanin in comparison with other natural antioxidants.

摘要

简介

黑色素由黑色素细胞产生，人们认为黑色素可以作为抗氧化剂，其依据是黑色素可以抑制电子激发态并清除自由基。

材料与方法

本研究旨在验证和证明金纳米粒子（GNPs）给药引起的毒性，并表征黑色素作为抗氧化剂在体内对抗由 GNPs 诱导的炎症性肝损伤、氧化应激和脂质过氧化的作用。

结果

这项研究的结果证实，腹腔内给予 GNPs 除了引起氧化应激和脂肪酸过氧化外，还会导致肝损伤。用黑色素和 GNPs 联合处理大鼠，导致所有测量的生化参数发生显著变化。我们的数据表明，黑色素完全抑制了炎症性肝损伤、氧化应激和脂质过氧化，这通过对不同肝组织切片进行 H&E 染色的组织学研究得到了证实。

结论

这些结果表明，将黑色素与 GNPs 一起使用可以减轻其毒性。其他研究应该考虑黑色素与其他天然抗氧化剂相比的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/33af0d3aa5dc/ijn-13-5207Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/a161a4e83680/ijn-13-5207Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/297f488cdaa8/ijn-13-5207Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/56b97d564929/ijn-13-5207Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/529fc77b9580/ijn-13-5207Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/59a539447bf8/ijn-13-5207Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/75811c652f1a/ijn-13-5207Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/33af0d3aa5dc/ijn-13-5207Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/a161a4e83680/ijn-13-5207Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/297f488cdaa8/ijn-13-5207Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/56b97d564929/ijn-13-5207Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/529fc77b9580/ijn-13-5207Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/59a539447bf8/ijn-13-5207Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/75811c652f1a/ijn-13-5207Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0935/6135214/33af0d3aa5dc/ijn-13-5207Fig7.jpg

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