Qin Lei, Kao Yi-Wei, Lin Yueh-Lung, Peng Bou-Yue, Deng Win-Ping, Chen Tsung-Ming, Lin Kuan-Chou, Yuan Kevin Sheng-Po, Wu Alexander Th, Shia Ben-Chang, Wu Szu-Yuan
School of Statistics, University of International Business and Economics, Beijing, China.
Graduate Institute of Business Administration, Fu Jen Catholic University, Taipei, Taiwan.
Cancer Manag Res. 2018 Sep 5;10:3273-3281. doi: 10.2147/CMAR.S168477. eCollection 2018.
Few studies have evaluated the risk of oral cavity cancer (OC) in patients with recurrent oral aphthae (ROA) and dry eye syndrome (DES). This study assessed the risk of OC in patients who had received diagnoses of ROA and DES in Taiwan.
A population-based frequency-matched case-control study was conducted in which data were analyzed from the National Health Insurance Research Database of Taiwan. Patients with ROA and DES were identified as the case cohort. Patients and controls without ROA and DES were frequency matched (1:4) on the basis of age, sex, monthly income, geographical location, and urbanization level. Chi-squared tests were conducted to compare demographic factor distributions between the patients and controls. Cox proportional hazards models were used to calculate the adjusted hazard ratios (aHRs) and 95% CI of OC diagnoses among the patients and controls. Risk consistency between the two cohorts was determined using subgroup analysis.
A total of 7,110 patients with ROA and DES and 28,388 controls were identified. The OC risk was significantly higher for female patients than controls (aHR=3.41, 95% CI=1.69-6.86). Furthermore, women aged 50-69 years exhibited a higher risk of OC than those in the other age groups. Female patients aged 50-59 years exhibited the highest aHR for OC (aHR=5.56, 95% CI=1.70-18.25), followed by those aged 60-69 years (aHR=4.34, 95% CI=1.26-15.99).
ROA and DES may be associated with a high risk of OC in elderly women.
很少有研究评估复发性口腔溃疡（ROA）和干眼症（DES）患者患口腔癌（OC）的风险。本研究评估了台湾地区诊断为ROA和DES的患者患OC的风险。
进行了一项基于人群的频率匹配病例对照研究，分析了台湾国民健康保险研究数据库中的数据。将ROA和DES患者确定为病例队列。根据年龄、性别、月收入、地理位置和城市化水平，对无ROA和DES的患者及对照进行频率匹配（1:4）。采用卡方检验比较患者和对照之间的人口统计学因素分布。使用Cox比例风险模型计算患者和对照中OC诊断的调整风险比（aHR）和95%置信区间。通过亚组分析确定两个队列之间的风险一致性。
共确定了7110例ROA和DES患者及28388例对照。女性患者患OC的风险显著高于对照（aHR = 3.41，95%置信区间 = 1.69 - 6.86）。此外，50 - 69岁的女性患OC的风险高于其他年龄组。50 - 59岁的女性患者患OC的aHR最高（aHR = 5.56，95%置信区间 = 1.70 - 18.25），其次是60 - 69岁的女性（aHR = 4.34，95%置信区间 = 1.26 - 15.99）。
ROA和DES可能与老年女性患OC的高风险相关。
