血液淋巴系统恶性肿瘤围绕着该家族中的女性：一例病例报告及文献综述。
Hemo-Lymphopoietic Malignancies Surround the Women of the Family: A Case Report and Literature Review.
作者信息
Kalantari-Khandani Behjat, Haghdoost Ali Akbar, Momeni Mohsen, Danaei Mina
机构信息
Department of Oncology, Kerman University of Medical Sciences, Kerman, Iran.
HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
Int J Hematol Oncol Stem Cell Res. 2018 Apr 1;12(2):92-97.
The co-occurrence of different types of hemo-lymphopoietic malignancies within a family provides clues about the pattern of inheritance and common environmental risk factors. A family presented with developing hemo-lymphopoietic cancers in three female first-degree relatives: a mother and her daughters. Case 1 was diagnosed with Walden Strom's macroglobulinemia at age 57. Case 2 and 3 presented with chronic myelogenous leukemia at age 32 and diffuse large B-cell lymphoma at age 28, respectively. There were not any significant common environmental risk factors in this family, but all three cases suffered from skin dermatitis and one of them, who suffered from chronic myelogenous leukemia, was diagnosed with morphea. This family had a sedentary and stressful lifestyle. Genetic is the foundation of some familial aggregation of cancers. Common lifestyle habits and environmental etiologies are important. Morphea as an autoimmune disease could have the essential role in developing hematolymphoid malignancies.
一个家族中不同类型血液淋巴系统恶性肿瘤的同时出现，为遗传模式和常见环境风险因素提供了线索。一个家族中有三名女性一级亲属患血液淋巴系统癌症：一位母亲及其两个女儿。病例1在57岁时被诊断为华氏巨球蛋白血症。病例2和病例3分别在32岁时患慢性粒细胞白血病，在28岁时患弥漫性大B细胞淋巴瘤。该家族没有任何显著的共同环境风险因素，但这三个病例均患有皮肤炎，其中一名患慢性粒细胞白血病的患者还被诊断出患有硬斑病。这个家族的生活方式久坐且压力大。遗传是某些癌症家族聚集性的基础。常见的生活习惯和环境病因很重要。硬斑病作为一种自身免疫性疾病，可能在血液淋巴系统恶性肿瘤的发生中起关键作用。
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