Korant B D, Towatari T, Ivanoff L, Petteway S, Brzin J, Lenarcic B, Turk V
J Cell Biochem. 1986;32(2):91-5. doi: 10.1002/jcb.240320202.
Antiviral activities of known protease inhibitors were assayed in virus-infected cell cultures. Some members of the cystatin superfamily, in particular chicken cystatin, were able to block virus replication. In a binding assay, using purified components, chicken and human cystatin were able to bind poliovirus protease with affinities which were reflected in their relative antiviral potencies. Prospects for application of protease inhibitors in clinical viral infections are discussed.
在病毒感染的细胞培养物中测定了已知蛋白酶抑制剂的抗病毒活性。胱抑素超家族的一些成员，特别是鸡胱抑素，能够阻断病毒复制。在一项使用纯化成分的结合试验中，鸡胱抑素和人胱抑素能够以反映其相对抗病毒效力的亲和力结合脊髓灰质炎病毒蛋白酶。文中讨论了蛋白酶抑制剂在临床病毒感染中的应用前景。
