一个保守的人类种系Vκ基因直接编码类风湿因子轻链。
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
作者信息
Radoux V, Chen P P, Sorge J A, Carson D A
出版信息
J Exp Med. 1986 Dec 1;164(6):2119-24. doi: 10.1084/jem.164.6.2119.
Abstract
The full-length gene that encodes the light chain variable regions of an idiotypically related group of human IgM kappa rheumatoid factors (RFs) has been cloned and sequenced. The deduced amino acid sequence is identical to four separate RF proteins. These results prove that genes capable of encoding human anti-IgG autoantibody light chains without any somatic mutation are present in the kappa gene repertoire of normal people.
摘要
编码一组独特型相关的人IgM κ类风湿因子（RFs）轻链可变区的全长基因已被克隆和测序。推导的氨基酸序列与四种不同的RF蛋白相同。这些结果证明，在正常人的κ基因库中存在能够编码无任何体细胞突变的人抗IgG自身抗体轻链的基因。
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