前B细胞系中最靠近连接区（JH）的重链可变区（VH）基因片段的优先利用。
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines.
作者信息
Yancopoulos G D, Desiderio S V, Paskind M, Kearney J F, Baltimore D, Alt F W
出版信息
Nature. 1984;311(5988):727-33. doi: 10.1038/311727a0.
DOI:10.1038/311727a0
PMID:6092962
Abstract
The most JH-proximal VH gene segments are used highly preferentially to form VHDJH rearrangements in pre-B-cell lines. This result demonstrates that the rate at which immunoglobulin VH gene segments recombine is influenced by their chromosomal organization, and that the initial repertoire of VH genes expressed in pre-B cells is strikingly different from that seen in mature populations.
摘要
在前B细胞系中，最靠近JH的VH基因片段被高度优先用于形成VHDJH重排。这一结果表明免疫球蛋白VH基因片段的重组速率受其染色体组织的影响，并且在前B细胞中表达的VH基因的初始库与成熟群体中所见的显著不同。
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