Department of Food Science and Dietetics, Wroclaw Medical University, Wroclaw, Poland.
Diagnostics Laboratory for Teaching and Research, Wroclaw Medical University, Wroclaw, Poland.
PLoS One. 2018 Sep 20;13(9):e0204173. doi: 10.1371/journal.pone.0204173. eCollection 2018.
Altered systemic redox status is often observed in lung cancer. However, detailed information on factors other, than smoking, which influence this perturbation is rather scarce. Elevated oxidative stress has been linked with disturbances in glucose metabolism before, but such associations have not been investigated in lung cancer. The aim of this study was to evaluate the relationship between systemic parameters of glucose metabolism and redox status in lung cancer patients (LC). Biochemical variables related to circulating glucose, i.e. glucose, insulin, c-peptide, fructosamine (FA), and glucose metabolism, i.e. β-hydroxybutyrate (BHB), lactate (LACT), non-esterified fatty acids (NEFAs), as well as redox status i.e. total antioxidant status (TAS) and total oxidant status (TOS) were determined for LC (n = 122) and control subjects (CS) (n = 84). HOMA-IR and the oxidative stress index (OSI) were calculated. LC patients had an altered redox status and glucose metabolism compared to CS. Positive correlations in LC were observed between TOS, OSI and circulating glucose as well as FA, while TAS positively correlated with BHB and NEFAs. In contrast, in metastatic LC, NEFAs and BHB positively correlated with OSI. Smoking status additionally stratified the observed relationships. In conclusion, we found that parameters related to circulating glucose or non-enzymatic glycation were correlated with oxidative stress (TOS and OSI), while metabolites such as BHB and NEFAs were correlated with antioxidant capacity (TAS). Metastasis prevalence and smoking seem to influence these correlations. However, the detailed mechanism of this relationship requires further research, in particular as regards the surprising positive correlation between NEFAs and TAS.
肺癌患者常伴有系统性氧化还原状态的改变。然而，除吸烟外，其他影响这种紊乱的因素的详细信息相当匮乏。氧化应激与葡萄糖代谢紊乱之前有联系，但肺癌中尚未对此相关性进行研究。本研究旨在评估肺癌患者（LC）系统性葡萄糖代谢和氧化还原状态之间的关系。测定与循环葡萄糖相关的生化变量，即葡萄糖、胰岛素、C 肽、果糖胺（FA）和葡萄糖代谢相关的变量，即β-羟丁酸（BHB）、乳酸（LACT）、非酯化脂肪酸（NEFAs）以及氧化还原状态，即总抗氧化状态（TAS）和总氧化状态（TOS）。将 LC（n=122）和对照受试者（CS）（n=84）的这些变量进行比较。计算 HOMA-IR 和氧化应激指数（OSI）。与 CS 相比，LC 患者的氧化还原状态和葡萄糖代谢发生了改变。在 LC 中观察到 TOS、OSI 与循环葡萄糖和 FA 呈正相关，而 TAS 与 BHB 和 NEFAs 呈正相关。相反，在转移性 LC 中，NEFAs 和 BHB 与 OSI 呈正相关。吸烟状况进一步划分了观察到的相关性。总之，我们发现与循环葡萄糖或非酶糖基化相关的参数与氧化应激（TOS 和 OSI）相关，而代谢物如 BHB 和 NEFAs 与抗氧化能力（TAS）相关。转移患病率和吸烟似乎影响这些相关性。然而，这种关系的详细机制需要进一步研究，特别是对于 NEFAs 和 TAS 之间令人惊讶的正相关关系。
