Lv Haiyan, Lv Huizhi, Lin Zhong, Chen Lihua, Zhu Min, Hong Dun
Public Laboratory, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai Anesthesia Deparment, Sanmen People's Hospital, Sanmen Pharmacy Department Department of Orthopedics, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.
Medicine (Baltimore). 2018 Sep;97(38):e12262. doi: 10.1097/MD.0000000000012262.
There is a considerable amount of literature on the potential relationship between human leukocyte antigen-G 14-bp Ins/Del polymorphism and virus infection; however, results from these studies were inconclusive.
A meta-analysis was carried out to determine whether the 14-bp Ins/Del polymorphism is a susceptible factor for virus infection.
Data were extracted from PubMed and Web of Science databases, and included 10 case-control studies (1835 patients and 2357 controls).
A total of 177 records from 10 studies were retrieved. Overall, no significant correlation was found between HLA-G 14-bp Ins/Del polymorphism and total viruses under all genetic models (dominant model: OR = 0.93, 95% CI = 0.68-1.29; recessive model: OR = 1.12, 95% CI = 0.84-1.48; deletion/deletion (DD) vs insertion/insertion (II): OR = 1.03, 95% CI = 0.71-1.49; deletion (D) vs insertion (I): OR = 1.01, 95% CI = 0.81-1.25). However, further subgroup analyses by virus type and ethnicity revealed that HLA-G 14-bp Ins/Del polymorphism was significantly associated with HTLV-1 infection in mixed population under the dominant model.
Our study demonstrated that HLA-G 14-bp Ins/Del polymorphism may not have any effect on susceptibility to viruses.
关于人类白细胞抗原-G 14碱基对插入/缺失多态性与病毒感染之间的潜在关系，已有大量文献报道；然而，这些研究结果尚无定论。
进行一项荟萃分析，以确定14碱基对插入/缺失多态性是否为病毒感染的易感因素。
从PubMed和Web of Science数据库中提取数据，纳入10项病例对照研究（1835例患者和2357例对照）。
从10项研究中检索到共计177条记录。总体而言，在所有遗传模型下，HLA-G 14碱基对插入/缺失多态性与总病毒感染之间均未发现显著相关性（显性模型：OR = 0.93，95% CI = 0.68 - 1.29；隐性模型：OR = 1.12, 95% CI = 0.84 - 1.48；缺失/缺失（DD）与插入/插入（II）：OR = 1.03, 95% CI = 0.71 - 1.49；缺失（D）与插入（I）：OR = 1.01, 95% CI = 0.81 - 1.25）。然而，按病毒类型和种族进行的进一步亚组分析显示，在显性模型下，混合人群中HLA-G 14碱基对插入/缺失多态性与人类嗜T淋巴细胞病毒1型（HTLV-1）感染显著相关。
我们的研究表明，HLA-G 14碱基对插入/缺失多态性可能对病毒易感性没有任何影响。
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