缺乏多瘤病毒DNA的野生小鼠中的乳腺肿瘤。
Mammary tumors in feral mice lacking MuMTV DNA.
作者信息
Gardner M B, Malone R W, Morris D W, Young L J, Strange R, Cardiff R D, Faulkin L J, Mitchell D J
出版信息
J Exp Pathol. 1985 Summer;2(2):93-8.
PMID:3023583
Abstract
Two mammary tumors developed in feral mice treated with dimethylbenzanthracene. The tumors, livers, and spleens of these animals contained no MuMTV proviral DNA. Neither tumor had amplified or rearranged int-1 or int-2 loci. This demonstrates that mammary tumorigenesis can occur in mice in the absence of endogenous and exogenous MuMTV.
摘要
在用二甲基苯并蒽处理的野生小鼠中出现了两个乳腺肿瘤。这些动物的肿瘤、肝脏和脾脏中均未检测到乳腺肿瘤病毒（MuMTV）前病毒DNA。两个肿瘤均未出现int-1或int-2基因座的扩增或重排。这表明在没有内源性和外源性MuMTV的情况下，小鼠也可发生乳腺肿瘤形成。
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