从泰国石松中分离得到的三个石松生物碱。
Three Lycopodium alkaloids from Thai club mosses.
机构信息
Program of Applied Biological Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy of Science, Laksi, Bangkok, 10210, Thailand.
Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Laksi, Bangkok, 10210, Thailand.
出版信息
Phytochemistry. 2018 Dec;156:83-88. doi: 10.1016/j.phytochem.2018.09.001. Epub 2018 Sep 17.
Phytochemical constituents in alkaloid extracts from three Thai club mosses Huperzia squarrosa, Huperzia phlegmaria and Phlegmariurus nummularifolius were investigated. Squarrosinoxide was an undescribed Lycopodium alkaloid from H. squarrosa possessing an unprecedented 6/5/7 tricyclic spiro system. Acetyllycophlegmarianol was an undescribed N-oxide lycopodine-type alkaloid isolated from H. phlegmaria. 4-Epilycopodine, an undescribed epimer of lycopodine, was first isolated from P. nummularifolius. The structural assignments were established through comprehensive spectroscopic techniques and chemical correlations. All compounds were assayed for their anti-acetylcholinesterase activity in vitro.
从三种泰国石松属植物粗枝石松、石杉和卷柏中提取的生物碱的植物化学成分进行了研究。 squarrosinoxide 是一种从未描述过的石松生物碱，来自 H. squarrosa，具有前所未有的 6/5/7 三环螺环系统。乙酰lycophlegmarianol 是一种从未描述过的 N-氧化物石松型生物碱，从 H. phlegmaria 中分离得到。4-Epilycopodine，一种未描述的石松差向异构体，首次从 P. nummularifolius 中分离得到。结构鉴定是通过综合光谱技术和化学相关性建立的。所有化合物均进行了体外抗乙酰胆碱酯酶活性测定。
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