Yang Qian, Zhu Yuquan, Peng Wei, Zhan Rui, Chen Yegao
a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
Nat Prod Res. 2016 Oct;30(19):2220-4. doi: 10.1080/14786419.2016.1146885. Epub 2016 Feb 25.
A new lycopodine-type alkaloid, 12β-hydroxy-acetylfawcettiine N-oxide (1), together with seven known analogues, acetyllycoposerramine M (2), lycopodine (3), lycoclavine (4), diphaladine A (5), lycoposerramine K (6), 11β-hydroxy-12-epilycodoline (7) and fawcettiine (8), were isolated from Lycopodium japonicum. Their structures were established by mass spectrometry and 1D and 2D NMR techniques. The isolated alkaloids were assayed for their inhibition activities against acetylcholinesterase, but no inhibitory activities for the compounds were detected.
从石松中分离出一种新的石松碱型生物碱12β-羟基-乙酰法氏石松碱N-氧化物（1），以及七种已知类似物，乙酰石松胺M（2）、石松碱（3）、石松麦角碱（4）、双法氏石松碱A（5）、石松胺K（6）、11β-羟基-12-表石松灵碱（7）和法氏石松碱（8）。通过质谱以及一维和二维核磁共振技术确定了它们的结构。对分离得到的生物碱进行了乙酰胆碱酯酶抑制活性测定，但未检测到这些化合物具有抑制活性。
