Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA
Harvard Medical School, Boston, MA.
Diabetes. 2018 Oct;67(10):1923-1931. doi: 10.2337/db18-0537.
The American Diabetes Association convened a research symposium, "Epigenetics and Epigenomics: Implications for Diabetes and Obesity" on 17-19 November 2017. International experts in genetics, epigenetics, computational biology, and physiology discussed the current state of understanding of the relationships between genetics, epigenetics, and environment in diabetes and examined existing evidence for the role of epigenetic factors in regulating metabolism and the risk of diabetes and its complications. The authors summarize the presentations, which highlight how the complex interactions between genes and environment may in part be mediated through epigenetic changes and how information about nutritional and other environmental stimuli can be transmitted to the next generation. In addition, the authors present expert consensus on knowledge gaps and research recommendations for the field.
美国糖尿病协会于 2017 年 11 月 17 日至 19 日召开了一次名为“表观遗传学和表观基因组学：对糖尿病和肥胖的影响”的研究研讨会。遗传学、表观遗传学、计算生物学和生理学领域的国际专家讨论了目前对遗传学、表观遗传学和环境之间关系的理解，并研究了表观遗传因素在调节代谢以及糖尿病及其并发症风险方面的作用的现有证据。作者总结了演讲内容，这些内容强调了基因和环境之间的复杂相互作用可能部分是通过表观遗传变化来介导的，以及关于营养和其他环境刺激的信息如何传递到下一代。此外，作者还就该领域的知识空白和研究建议提出了专家共识。
