Jilo Diba Dedacha, Abebe Belete Kuraz, Wang Jianfang, Guo Juntao, Li Anning, Zan Linsen
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Department of Animal Science, Bule Hora University, Bule Hora, Ethiopia.
Front Genet. 2024 Oct 3;15:1405588. doi: 10.3389/fgene.2024.1405588. eCollection 2024.
Investigating the involvement of long non-coding RNAs (lncRNAs) and epigenetic processes in bovine adipocytes can provide valuable new insights into controlling adipogenesis in livestock. Long non-coding RNAs have been associated with forming chromatin loops that facilitate enhancer-promoter interactions during adipogenesis, as well as regulating important adipogenic transcription factors like C/EBPα and PPARγ. They significantly influence gene expression regulation at the post-transcriptional level and are extensively researched for their diverse roles in cellular functions. Epigenetic modifications such as chromatin reorganization, histone alterations, and DNA methylation subsequently affect the activation of genes related to adipogenesis and the progression of adipocyte differentiation. By investigating how fat deposition is epigenetically regulated in beef cattle, scientists aim to unravel molecular mechanisms, identify key regulatory genes and pathways, and develop targeted strategies for modifying fat deposition to enhance desirable traits such as marbling and meat tenderness. This review paper delves into lncRNAs and epigenetic factors and their role in regulating bovine adipocytes while focusing on their potential as targets for genetic improvement to increase production efficiency. Recent genomics advancements, including molecular markers and genetic variations, can boost animal productivity, meeting global demands for high-quality meat products. This review establishes a foundation for future research on understanding regulatory networks linked to lncRNAs and epigenetic changes, contributing to both scholarly knowledge advancement and practical applications within animal agriculture.
研究长链非编码RNA（lncRNAs）和表观遗传过程在牛脂肪细胞中的作用，可为控制家畜脂肪生成提供有价值的新见解。长链非编码RNA与形成染色质环有关，染色质环在脂肪生成过程中促进增强子-启动子相互作用，同时还调节重要的脂肪生成转录因子，如C/EBPα和PPARγ。它们在转录后水平上显著影响基因表达调控，并因其在细胞功能中的多种作用而受到广泛研究。诸如染色质重组、组蛋白改变和DNA甲基化等表观遗传修饰随后会影响与脂肪生成相关的基因的激活以及脂肪细胞分化的进程。通过研究肉牛脂肪沉积的表观遗传调控方式，科学家旨在揭示分子机制，识别关键调控基因和途径，并制定针对性策略来改变脂肪沉积，以增强诸如大理石花纹和肉嫩度等理想性状。这篇综述文章深入探讨了lncRNAs和表观遗传因子及其在调节牛脂肪细胞中的作用，同时关注它们作为遗传改良靶点以提高生产效率的潜力。包括分子标记和基因变异在内的最新基因组学进展，可以提高动物生产力，满足全球对高品质肉类产品的需求。这篇综述为未来研究理解与lncRNAs和表观遗传变化相关的调控网络奠定了基础，有助于动物农业领域的学术知识进步和实际应用。
