不同乳腺癌分子亚型的扩散加权成像：系统评价与荟萃分析
Diffusion-Weighted Imaging of Different Breast Cancer Molecular Subtypes: A Systematic Review and Meta-Analysis.
作者信息
Meyer Hans-Jonas, Wienke Andreas, Surov Alexey
机构信息
Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.
Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
出版信息
Breast Care (Basel). 2022 Feb;17(1):47-54. doi: 10.1159/000514407. Epub 2021 Feb 23.
BACKGROUND
Magnetic resonance imaging can be used to diagnose breast cancer (BC). Diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) can be used to reflect tumor microstructure.
OBJECTIVES
This analysis aimed to compare ADC values between molecular subtypes of BC based on a large sample of patients.
METHOD
The MEDLINE library and Scopus database were screened for the associations between ADC and molecular subtypes of BC up to April 2020. The primary end point of the systematic review was the ADC value in different BC subtypes. Overall, 28 studies were included.
RESULTS
The included studies comprised a total of 2,990 tumors. Luminal A type was diagnosed in 865 cases (28.9%), luminal B in 899 (30.1%), human epidermal growth factor receptor (Her2)-enriched in 597 (20.0%), and triple-negative in 629 (21.0%). The mean ADC values of the subtypes were as follows: luminal A: 0.99 × 10 mm/s (95% CI 0.94-1.04), luminal B: 0.97 × 10 mm/s (95% CI 0.89-1.05), Her2-enriched: 1.02 × 10 mm/s (95% CI 0.95-1.08), and triple-negative: 0.99 × 10 mm/s (95% CI 0.91-1.07).
CONCLUSIONS
ADC values cannot be used to discriminate between molecular subtypes of BC.
背景
磁共振成像可用于诊断乳腺癌（BC）。扩散加权成像（DWI）和表观扩散系数（ADC）可用于反映肿瘤微观结构。
目的
本分析旨在基于大量患者样本比较BC分子亚型之间的ADC值。
方法
检索MEDLINE数据库和Scopus数据库，以查找截至2020年4月ADC与BC分子亚型之间的关联。系统评价的主要终点是不同BC亚型中的ADC值。总共纳入了28项研究。
结果
纳入的研究共包含2990个肿瘤。管腔A型诊断出865例（28.9%），管腔B型899例（30.1%），人表皮生长因子受体（Her2）富集型597例（20.0%），三阴性629例（21.0%）。各亚型的平均ADC值如下：管腔A：0.99×10⁻³mm²/s（95%CI 0.94 - 1.04），管腔B：0.97×10⁻³mm²/s（95%CI 0.89 - 1.05），Her2富集型：1.02×10⁻³mm²/s（95%CI 0.95 - 1.08），三阴性：0.99×10⁻³mm²/s（95%CI 0.91 - 1.07）。
结论
ADC值不能用于区分BC的分子亚型。
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