利用穿梭载体系统测定甲磺酸乙酯在人细胞中诱导的DNA序列变化。
Determination of DNA sequence changes induced by ethyl methanesulfonate in human cells, using a shuttle vector system.
作者信息
Lebkowski J S, Miller J H, Calos M P
出版信息
Mol Cell Biol. 1986 May;6(5):1838-42. doi: 10.1128/mcb.6.5.1838-1842.1986.
Abstract
The DNA sequence changes for 54 mutations induced in human cells by the alkylating agent ethyl methanesulfonate are reported. The mutations were obtained by using a shuttle vector system with the bacterial lacI gene as the target. Of the 54 mutations obtained, 53 were G:C to A:T transitions.
摘要
报道了由烷化剂甲磺酸乙酯在人类细胞中诱导产生的54个突变的DNA序列变化。这些突变是通过使用以细菌lacI基因作为靶标的穿梭载体系统获得的。在获得的54个突变中，53个是G:C到A:T的转换。
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