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玻璃体内注射地塞米松植入物治疗白内障术后葡萄膜炎患者的疗效。

Efficacy of Intravitreal Dexamethasone Implant in Patients of Uveitis Undergoing Cataract Surgery.

机构信息

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

出版信息

Ocul Immunol Inflamm. 2019;27(8):1330-1338. doi: 10.1080/09273948.2018.1524498. Epub 2018 Sep 21.

Abstract

: To assess postoperative inflammation using laser flare photometer, following phacoemulsification with or without single intraoperative intravitreal dexamethasone implant in addition to standard of care, in patients of uveitis with cataract.: Prospectively, 30 eyes with uveitic cataract were randomized into 2 groups (i) standard of care (SOC group) (ii) Dexamethasone implant (DEXA group). Both the groups underwent phacoemulsification with intraocular lens implantation and standard of care treatment for uveitis, but DEXA group additionally received intraoperative intravitreal dexamethasone implant. Patients were followed at least till 6 months.: DEXA group had significantly less postoperative flare (LFP values) (P<0.05) as compared to SOC group and also recovery of flare to preoperative value occurred much early in DEXA group. 37.5% cases developed CME in SOC group but none in DEXA group. Mean CMT (267.81±34.26μm) and final logMar BCVA (0.036±0.063) was significantly better in DEXA group (<0.04).: Intraoperative intravitreal dexamethasone implant is a safe and effective option for preventing and managing the postoperative inflammation in uveitic cataract.

摘要

: 评估激光闪辉光度计术后炎症,在常规护理基础上,对合并白内障的葡萄膜炎患者进行超声乳化术并分别额外使用或不使用术中单次玻璃体内地塞米松植入物:前瞻性地,将 30 只患有葡萄膜炎合并白内障的眼随机分为 2 组(i)标准护理组(SOC 组)(ii)地塞米松植入物组(DEXA 组)。两组均行超声乳化白内障吸除术和眼内人工晶状体植入术及常规护理治疗葡萄膜炎,但 DEXA 组额外接受术中玻璃体内地塞米松植入物治疗。患者至少随访 6 个月。:DEXA 组术后闪光(LFP 值)明显较低(P<0.05),与 SOC 组相比,DEXA 组的闪光恢复至术前值的时间也更早。SOC 组有 37.5%的病例发生 CME,但 DEXA 组没有。DEXA 组的平均 CMT(267.81±34.26μm)和最终 logMar BCVA(0.036±0.063)明显更好(<0.04)。:术中玻璃体内地塞米松植入物是一种安全有效的选择,可预防和控制葡萄膜炎性白内障术后炎症。

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