Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India.
Department of Pediatrics, Division of Allergy and Immunology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India.
Indian J Ophthalmol. 2019 Jan;67(1):69-74. doi: 10.4103/ijo.IJO_713_18.
To assess the safety and efficacy of intraoperative intravitreal dexamethasone implant in patients of juvenile idiopathic arthritis (JIA)-associated uveitis undergoing phacoemulsification with posterior chamber intraocular lens (PCIOL) implantation.
Retrospectively, data of patients with JIA-associated uveitis undergoing phacoemulsification with PCIOL implantation with intraoperative dexamethasone implant injection were analyzed. Patients with a minimum follow-up of 6 months were included. Primary outcome measures were ocular inflammation, intraocular pressure (IOP), best-corrected visual acuity (BCVA), and worsening of uveitis.
8 eyes of 6 patients were included. BCVA was significantly improved at 1, 3, and 6 months postoperatively 0.20 ± 0.09, P = 0.008; 0.18 ± 0.11, P = 0.008; and 0.24 ± 0.11, P = 0.01, respectively. No statistical difference noted in mean IOP at various follow-up visits. None developed worsening of uveitis or Cystoid macular edema.
Intraoperative intravitreal dexamethasone implant is a safe and effective in preventing and managing the postoperative inflammation in children with JIA-associated uveitic cataract.
评估术中玻璃体内注射地塞米松植入物在接受超声乳化白内障吸除术联合后房型人工晶状体（PCIOL）植入术的幼年特发性关节炎（JIA）相关性葡萄膜炎患者中的安全性和疗效。
回顾性分析了接受超声乳化白内障吸除术联合后房型人工晶状体植入术并术中注射地塞米松植入物的 JIA 相关性葡萄膜炎患者的数据。纳入至少随访 6 个月的患者。主要观察指标为眼内炎症、眼内压（IOP）、最佳矫正视力（BCVA）和葡萄膜炎恶化情况。
纳入 6 例患者的 8 只眼。术后 1、3 和 6 个月时 BCVA 显著提高，分别为 0.20 ± 0.09（P = 0.008）、0.18 ± 0.11（P = 0.008）和 0.24 ± 0.11（P = 0.01）。各随访时间点的平均 IOP 无统计学差异。均未发生葡萄膜炎恶化或囊样黄斑水肿。
术中玻璃体内注射地塞米松植入物是一种安全有效的方法，可预防和治疗 JIA 相关性葡萄膜炎合并白内障患儿的术后炎症。
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