小儿嗜酸性食管炎：基层医疗环境的最新进展。
Pediatric eosinophilic esophagitis: updates for the primary care setting.
机构信息
The Children's Hospital of Philadelphia, Division of Allergy and Immunology, Department of Pediatrics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, USA.
出版信息
Curr Opin Pediatr. 2018 Dec;30(6):829-836. doi: 10.1097/MOP.0000000000000698.
PURPOSE OF REVIEW
Eosinophilic esophagitis (EoE) is a multifactorial, non-IgE-mediated inflammatory disorder of the esophagus and is the most common cause of food impaction in the pediatric population. The purpose of this review is to describe the current recommendations for diagnosis and management of EoE.
RECENT FINDINGS
New data has associated EoE with other allergic disorders of the atopic march as well as several risk factors, which predispose to allergic conditions. A subset of patients with esophageal eosinophilia respond to proton pump inhibitor (PPI) therapy with a partial or complete resolution of esophageal eosinophilia. Therefore, some patients can be treated with PPI alone. If this is unsuccessful, dietary elimination and swallowed steroid therapy are recommended for long-term management. There is a growing appreciation that untreated esophageal inflammation can lead to complications of fibrosis and stricture formation.
SUMMARY
The current review will focus on the diagnosis and management of EoE in the pediatric population. Identification and diagnosis of pediatric patients with EoE is critical to prevent long-term esophageal complications.
目的综述
嗜酸性粒细胞性食管炎（EoE）是一种多因素、非 IgE 介导的食管炎症性疾病，也是儿童人群中食物嵌塞的最常见原因。本文的目的在于描述 EoE 的诊断和治疗的最新推荐。
最近的发现
新数据将 EoE 与特应性进行曲中的其他过敏性疾病以及几种易患过敏的危险因素联系起来。食管嗜酸性粒细胞增多症患者中的一部分对质子泵抑制剂（PPI）治疗有反应，食管嗜酸性粒细胞增多症部分或完全消退。因此，一些患者可以单独接受 PPI 治疗。如果不成功，建议进行饮食排除和口服类固醇治疗以进行长期管理。人们越来越认识到，未经治疗的食管炎症可导致纤维化和狭窄形成等并发症。
总结
本综述将重点关注儿科人群中 EoE 的诊断和管理。识别和诊断儿科 EoE 患者对于预防长期食管并发症至关重要。
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