Department of Chemistry , Colorado State University , Fort Collins , Colorado 80523 , United States.
J Phys Chem B. 2018 Oct 18;122(41):9555-9566. doi: 10.1021/acs.jpcb.8b07406. Epub 2018 Oct 5.
The research presented here reports the surprising observation that adding glucose and other carbohydrate osmolytes to the polar phase of water-containing reverse micelles causes the particles to shrink. This apparent change in reverse micelle size is attributed to two factors: an increase in the surface area per surfactant molecule induced by the presence of carbohydrate and changes in the particle shape eccentricity. The studies reported here not only focus on glucose but also explore other carbohydrate osmolytes, specifically ethylene glycol, glycerol, erythritol, xylitol, sorbitol, myo-inositol, and trehalose, in the nanoconfined environments of reverse micelles. Through two-dimensional proton nuclear Overhauser enhancement nuclear magnetic resonance spectroscopy, the osmolytes were determined to reside solvated in the aqueous interior of the reverse micelles. This paper reports the loading limit of carbohydrates into AOT [sodium bis(2-ethylhexyl)sulfosuccinate] reverse micelles, demonstrates the location of the carbohydrates in the reverse micelles, and shows an unexpected effect where the carbohydrates add to the reverse micelle volume without causing an apparent increase in the reverse micelle diameter.
本研究报告了一个令人惊讶的观察结果，即在含有水的反胶束的极性相中添加葡萄糖和其他碳水化合物渗透剂会导致颗粒收缩。这种反胶束尺寸的明显变化归因于两个因素：碳水化合物的存在诱导的表面活性剂分子的表面积增加和颗粒形状偏心度的变化。这里报道的研究不仅关注葡萄糖，还探索了其他碳水化合物渗透剂，特别是乙二醇、甘油、赤藓糖醇、木糖醇、山梨糖醇、肌醇和海藻糖，在反胶束的纳米受限环境中。通过二维质子核 Overhauser 增强核磁共振波谱，确定渗透剂溶解在反胶束的水相中。本文报告了碳水化合物在 AOT（二(2-乙基己基)磺基琥珀酸钠）反胶束中的加载极限，证明了碳水化合物在反胶束中的位置，并显示了一种意想不到的效果，即碳水化合物加入反胶束体积而不会导致反胶束直径的明显增加。
