Totterdell S, Smith A D
Neuroscience. 1986 Sep;19(1):181-92. doi: 10.1016/0306-4522(86)90014-x.
Neurons in the hippocampal formation of the rat that project to the medial nucleus accumbens were identified following the retrograde transport of a conjugate of horseradish peroxidase with wheat germ agglutinin. The great majority of such projecting neurons were located in the ventral subiculum and were pyramidal in shape; the pyramidal nature of 25 such retrogradely labelled neurons was established by Golgi impregnation. In material processed to reveal both retrogradely labelled cells and cholecystokinin-immunoreactivity, no immunoreactive projecting neurons were found. However, 48 identified projecting neurons, probably pyramidal, were found to receive input from cholecystokinin-immunoreactive boutons that formed symmetrical synaptic contacts with the soma or proximal dendrites. It is suggested that one function of cholecystokinin-immunoreactive neurons in the hippocampal formation might be to influence the output of the pyramidal neurons that project to the nucleus accumbens. Since this pathway is one of the main links between the limbic system and the basal ganglia, it is conceivable that changes in the cholecystokinin levels in the hippocampus, as found in schizophrenia, might influence behaviour through the pathway connecting the hippocampus with the nucleus accumbens.
利用辣根过氧化物酶与小麦胚芽凝集素的结合物逆行运输，鉴定了大鼠海马结构中投射到伏隔核内侧的神经元。绝大多数此类投射神经元位于腹侧下托，呈锥形；通过高尔基染色法确定了25个此类逆行标记神经元的锥形特征。在用于显示逆行标记细胞和胆囊收缩素免疫反应性的材料中，未发现免疫反应性投射神经元。然而，发现48个已鉴定的投射神经元（可能是锥形神经元）接受来自胆囊收缩素免疫反应性终扣的输入，这些终扣与胞体或近端树突形成对称突触联系。有人提出，海马结构中胆囊收缩素免疫反应性神经元的一个功能可能是影响投射到伏隔核的锥形神经元的输出。由于该通路是边缘系统与基底神经节之间的主要联系之一，因此可以想象，精神分裂症患者海马中胆囊收缩素水平的变化可能通过连接海马与伏隔核的通路影响行为。
