Laboratory of Neuropsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, 110231, Bogotá, Colombia.
Department of Clinical Psychology and Psychobiology, School of Psychology, University of Barcelona, Barcelona, Spain.
Mol Brain. 2018 Sep 21;11(1):53. doi: 10.1186/s13041-018-0397-0.
Genetic studies of major depressive disorder and its associated endophenotypes are useful for the identification of candidate genes. In recent years, variations in non-coding RNA genes, such as miRNAs, have been explored as novel candidates for psychiatric disorders and related endophenotypes. The aim of the present study was to evaluate the possible association between a functional polymorphism (rs12720208) in the FGF20 gene, which regulates its modulation by miR-433, and depressive symptoms in young adults. A sample of 270 participants from Colombia were evaluated with the Hospital Anxiety and Depression Scale - Depression Subscale (HADS-D) and genotyped for the rs12720208 polymorphism using a TaqMan assay. A lineal regression analysis was used. A statistically significant association of the functional polymorphism in the FGF20 gene (rs12720208) with depressive symptoms was found. It was observed that individuals with the G/A genotype had higher scores for the HADS-D subscale. Our results are the first description in the scientific literature about a significant association between a functional polymorphism in the FGF20 gene, which regulates its modulation by miR-433, and depressive symptoms.
遗传研究重度抑郁症及其相关的内表型对于候选基因的鉴定很有用。近年来，非编码 RNA 基因（如 miRNA）的变异已被探索为精神疾病和相关内表型的新型候选基因。本研究旨在评估 FGF20 基因中功能性多态性（rs12720208）与年轻成年人抑郁症状之间可能的关联，该基因调节其受 miR-433 的调控。来自哥伦比亚的 270 名参与者的样本用医院焦虑和抑郁量表 - 抑郁分量表（HADS-D）进行评估，并使用 TaqMan 测定法对 rs12720208 多态性进行基因分型。使用线性回归分析。FGF20 基因（rs12720208）的功能性多态性与抑郁症状之间存在统计学显著关联。观察到具有 G/A 基因型的个体的 HADS-D 子量表评分更高。我们的研究结果是关于 FGF20 基因（rs12720208）的功能性多态性与 miR-433 调节的抑郁症状之间存在显著关联的科学文献中的首次描述。
