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DRD1基因中的一个功能性多态性可调节其受miR - 504的调控，该多态性与抑郁症状相关。

A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms.

作者信息

Jiménez Karen M, Pereira-Morales Angela J, Forero Diego A

机构信息

Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia.

出版信息

Psychiatry Investig. 2018 Apr;15(4):402-406. doi: 10.30773/pi.2017.10.16.1. Epub 2018 Apr 5.

DOI:10.30773/pi.2017.10.16.1
PMID:29614853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5912498/
Abstract

OBJECTIVE

The aim of this study was to examine a possible association between depressive symptoms and a functional polymorphism (rs686) that modulates the regulation of DRD1 gene by miR-504.

METHODS

A total of 239 young Colombian subjects were evaluated with the Patient Health Questionnaire-9 (PHQ-9) scale and genotyped for the rs686 polymorphism. A linear regression model, corrected by age and gender, was used.

RESULTS

A significant association between the rs686 polymorphism and PHQ-9 scores was found, under a dominant genetic model (p=0.0094).

CONCLUSION

These results provide novel evidence about the growing role of inherited variants in binding sites for brain-expressed miRNAs on depressive symptomatology.

摘要

目的

本研究旨在探讨抑郁症状与一种功能性多态性（rs686）之间的可能关联，该多态性通过miR - 504调节DRD1基因的调控。

方法

对总共239名年轻的哥伦比亚受试者进行了患者健康问卷 - 9（PHQ - 9）量表评估，并对rs686多态性进行基因分型。使用了经年龄和性别校正的线性回归模型。

结果

在显性遗传模型下，发现rs686多态性与PHQ - 9评分之间存在显著关联（p = 0.0094）。

结论

这些结果为大脑表达的微小RNA结合位点上的遗传变异在抑郁症状学中日益增长的作用提供了新的证据。