Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Mol Cell. 2018 Sep 20;71(6):875-876. doi: 10.1016/j.molcel.2018.09.006.
In this issue of Molecular Cell, Liu et al. (2018) show that PI34P2 and PIP3, the lipid products of class I phosphoinositide 3-kinase (PI3K), display distinct spatiotemporal kinetics in cells that result in differential activation of the effectors AKT1, AKT2, and AKT3.
在本期《分子细胞》中,刘等人(2018 年)表明,PI34P2 和 PIP3,即 I 类磷酸肌醇 3-激酶(PI3K)的脂质产物,在细胞中表现出不同的时空动力学,从而导致效应物 AKT1、AKT2 和 AKT3 的差异化激活。