偏头痛和丛集性头痛——共同的联系。
Migraine and cluster headache - the common link.
机构信息
Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Health Sciences Department, University of Florence and Headache Centre, Careggi University Hospital, Florence, Italy.
出版信息
J Headache Pain. 2018 Sep 21;19(1):89. doi: 10.1186/s10194-018-0909-4.
Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients.
尽管在临床上可以区分，但偏头痛和丛集性头痛有一些显著的共同特征，如单侧疼痛、常见的药理学触发因素（如硝酸甘油、组胺、降钙素基因相关肽 [CGRP]）以及对曲坦类药物和神经调节的反应。最近的数据还表明，抗 CGRP 单克隆抗体在偏头痛和丛集性头痛中都有效。虽然这两种疾病的确切机制仍有待充分理解，但三叉神经血管系统代表了一种可能的共同病理生理途径和两种疾病的网络。在这里，我们回顾了过去和现在的文献，探讨了偏头痛和丛集性头痛在表型、遗传性、病理生理学、影像学发现和治疗选择方面的异同。持续关注它们共同的病理生理途径可能对开辟未来的治疗途径很重要，这可能使偏头痛和丛集性头痛患者都受益。
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