晚年双相情感障碍中衰老相关分泌表型指数升高。
Elevated senescence-associated secretory phenotype index in late-life bipolar disorder.
机构信息
Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.
UConn Center on Aging & Department of Psychiatry, UConn School of Medicine, University of Connecticut Health Center, United States of America.
出版信息
J Affect Disord. 2024 Sep 1;360:163-168. doi: 10.1016/j.jad.2024.05.071. Epub 2024 May 23.
BACKGROUND
The senescence-associated secretory phenotype (SASP) is a biomarker index based on the profile of 22 blood proteins associated with cellular senescence. The SASP index has not been assessed in older patients with bipolar disorder (BD). We hypothesized that older adults with BD will have elevated cellular senescence burden as measured by the SASP index.
METHODS
We measured the 22 SASP proteins to calculate the SASP index in 38 older patients with BD and 34 non-psychiatric comparison individuals (HC).
RESULTS
The SASP index scores were significantly higher in BD than HC after controlling for age, sex, psychopathology, and physical health (F(1,8) = 5.37, p = 0.024, η2 = 0.08). SASP index scores were also associated with higher age, more severe depressive symptoms, and physical illness burden (p < 0.05) in the whole sample.
LIMITATION
Cross-sectional study and small sample size.
CONCLUSION
This is the first report of increased SASP index scores in older adults with BD. Our results suggest that dysregulation of age-related biological processes may contribute to more severe depressive symptoms and worse physical health in older adults with BD.
背景
衰老相关分泌表型（SASP）是一种基于与细胞衰老相关的 22 种血液蛋白特征的生物标志物指标。尚未在老年双相情感障碍（BD）患者中评估 SASP 指数。我们假设，BD 的老年患者的细胞衰老负担会通过 SASP 指数升高。
方法
我们测量了 38 名老年 BD 患者和 34 名非精神病对照个体（HC）的 22 种 SASP 蛋白，以计算 SASP 指数。
结果
在控制年龄、性别、精神病理学和身体健康状况后，BD 患者的 SASP 指数得分明显高于 HC（F（1，8）= 5.37，p = 0.024，η2 = 0.08）。在整个样本中，SASP 指数得分也与年龄较大、更严重的抑郁症状和身体疾病负担有关（p < 0.05）。
局限性
横断面研究和样本量小。
结论
这是首次报道老年 BD 患者 SASP 指数得分升高。我们的结果表明，与年龄相关的生物学过程失调可能导致老年 BD 患者出现更严重的抑郁症状和更差的身体健康状况。
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