Hacettepe University, Faculty of Pharmacy, Department of Radiopharmacy, 06100 Sıhhiye, Ankara, Turkey.
Int J Pharm. 2018 Nov 15;551(1-2):329-338. doi: 10.1016/j.ijpharm.2018.09.019. Epub 2018 Sep 19.
Near-Infrared (NIR) dyes forming some of the photosensitizer agents show imaging and therapy features by themselves. NIR dyes show photodynamic therapy by formation of reactive oxygen species and imaging by NIR Fluorescence light. Photodynamic therapy occurs from irradiation of laser or light to photosensitizer matters and following by the formation of reactive oxygen species diseased tissues or cells can be killed effectively. NIR dyes have advantages such as stability, high specificity and sensitivity when compared with the other photosensitizer and imaging agents. Drug delivery systems are getting attention for either diagnosis or therapy of almost all of the diseases. Theranostic nanoparticles comprise the substances which shows the imaging and treatment features together. Besides, the combination of active substance and the imaging agent can also be encapsulated in theranostic nanoparticles. Many researchs are performed to evaluate the efficacy of theranostic drug delivery systems particularly polymeric nanoparticles in order to enhance targeting properties, specificity and bioavailability. Polymeric nanoparticles give advantages because of easier degradation properties when compared with the others. Theranostic polymeric nanoparticles can be used for NIR imaging and photodynamic therapy of several diseases especially cancers.
近红外 (NIR) 染料本身形成一些光敏剂，具有成像和治疗特性。NIR 染料通过形成活性氧来进行光动力治疗，并通过 NIR 荧光光进行成像。光动力疗法是通过激光或光照射光敏物质，随后形成活性氧，从而有效杀死病变组织或细胞。与其他光敏剂和成像剂相比，NIR 染料具有稳定性、高特异性和灵敏度等优点。药物输送系统因其在几乎所有疾病的诊断或治疗方面的应用而受到关注。治疗诊断纳米粒子包含了同时具有成像和治疗特征的物质。此外，活性物质和成像剂的组合也可以封装在治疗诊断纳米粒子中。为了增强靶向性、特异性和生物利用度，许多研究都在评估治疗诊断药物输送系统（特别是聚合物纳米粒子）的疗效。与其他物质相比，聚合物纳米粒子更容易降解，具有优势。治疗诊断聚合物纳米粒子可用于几种疾病（特别是癌症）的 NIR 成像和光动力治疗。
