Colin Ratledge Center for Microbial Lipids, School of Agriculture Engineering and Food Science, Shandong University of Technology, Zibo 255049, China.
School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Malaysia.
Biomed Res Int. 2018 Aug 29;2018:3428437. doi: 10.1155/2018/3428437. eCollection 2018.
The potential health benefits of probiotics have long been elucidated since Metchnikoff and his coworkers postulated the association of probiotic consumption on human's health and longevity. Since then, many scientific findings and research have further established the correlation of probiotic and gut-associated diseases such as irritable bowel disease and chronic and antibiotic-associated diarrhea. However, the beneficial impact of probiotic is not limited to the gut-associated diseases alone, but also in different acute and chronic infectious diseases. This is due to the fact that probiotics are able to modify the intestinal microbial ecosystem, enhance the gut barrier function, provide competitive adherence to the mucosa and epithelium, produce antimicrobial substances, and modulate the immune activity by enhancing the innate and adaptive immune response. Nevertheless, the current literature with respect to the association of probiotic and cancer, high serum cholesterol, and allergic and HIV diseases are still scarce and controversial. Therefore, in the present work, we reviewed the potential preventive and therapeutic role of probiotics for cancer, high serum cholesterol, and allergic and HIV diseases as well as providing its possible mechanism of actions.
自从梅契尼科夫及其同事提出益生菌消费与人类健康和长寿之间的关联以来，益生菌的潜在健康益处早已得到阐明。此后，许多科学发现和研究进一步证实了益生菌与肠道相关疾病（如肠易激综合征和慢性和抗生素相关性腹泻）之间的相关性。然而，益生菌的有益影响不仅限于肠道相关疾病，还包括不同的急性和慢性传染病。这是因为益生菌能够改变肠道微生物生态系统，增强肠道屏障功能，提供对黏膜和上皮的竞争黏附，产生抗菌物质，并通过增强先天和适应性免疫反应来调节免疫活性。然而，目前关于益生菌与癌症、高血清胆固醇、过敏和 HIV 疾病的关联的文献仍然很少且存在争议。因此，在本研究中，我们综述了益生菌在癌症、高血清胆固醇、过敏和 HIV 疾病中的预防和治疗作用及其可能的作用机制。
