Srigley Cynthia T, Orr-Tokle Isa C
Center for Food Safety and Applied Nutrition (CFSAN), United States Food and Drug Administration (FDA), 5001 Campus Drive, College Park, MD, 20740, USA.
Lipids. 2018 Jul;53(7):749-754. doi: 10.1002/lipd.12078. Epub 2018 Sep 23.
Krill oil dietary supplements are increasingly used for their high concentrations of phospholipids (PL), which offer reportedly greater bioavailability of n-3 polyunsaturated fatty acids (PUFA) than those of triacylglycerols or fatty-acid ethyl esters (FAEE) commonly found in fish oils and fish-oil concentrates. This work evaluated the lipid composition of 22 commercial krill oil (CKO) supplements available in the US market, and found ten products (i.e. 45%) contained significant amounts of FAEE, varying from 41% to 75%, by weight. These concentrations of FAEE differed from the minor abundances of FAEE (<3%, by weight) found in manufacturer-supplied krill oil. The potential clinical and regulatory implications for these findings warrant further investigation.
磷虾油膳食补充剂因其高浓度的磷脂（PL）而越来越多地被使用，据报道，与鱼油和鱼油浓缩物中常见的三酰甘油或脂肪酸乙酯（FAEE）相比，磷脂能使n-3多不饱和脂肪酸（PUFA）具有更高的生物利用度。这项研究评估了美国市场上22种市售磷虾油（CKO）补充剂的脂质成分，发现有10种产品（即45%）含有大量的FAEE，按重量计算，其含量从41%到75%不等。这些FAEE的浓度与制造商提供的磷虾油中发现的少量FAEE（按重量计<3%）不同。这些发现的潜在临床和监管意义值得进一步研究。
