Nazli Adila, Baig Muhammad Waleed, Zia Muhammad, Ali Muhammad, Shinwari Zabta Khan, Haq Ihsan Ul
Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan.
IET Nanobiotechnol. 2018 Oct;12(7):869-878. doi: 10.1049/iet-nbt.2017.0325.
Theranostic approach provides us a platform where diagnosis and treatment can be carried out simultaneously. Biosynthesis of theranostic-capable nanoparticles (NPs) can be carried out by phytoconstituents present inside the plants that can act as capping as well as stabilising agents by offering several advantages over chemical and physical methods. This article highlights the theranostic role of NPs with emphasis on potential of plants to produce these NPs through ecofriendly approach that is called 'Green synthesis'. Biosynthesis, advantages, and disadvantages of plant-based theronostics have been discussed for better understanding. Moreover, this article has highlighted the approaches required to optimise the plant-mediated synthesis of NPs and to avoid the toxicity of these agents. Anticipating all of the challenges, the authors expect biogenic NPs can appear as potential diagnostic and therapeutic agents in near future.
诊疗一体化方法为我们提供了一个可同时进行诊断和治疗的平台。具有诊疗能力的纳米颗粒（NPs）的生物合成可由植物体内的植物成分来完成，这些植物成分可作为封端剂和稳定剂，相较于化学和物理方法具有多种优势。本文重点介绍了纳米颗粒的诊疗作用，强调了植物通过被称为“绿色合成”的环保方法生产这些纳米颗粒的潜力。为了更好地理解，本文讨论了基于植物的诊疗方法的生物合成、优点和缺点。此外，本文还强调了优化植物介导的纳米颗粒合成以及避免这些制剂毒性所需的方法。考虑到所有这些挑战，作者预计生物源纳米颗粒在不久的将来可能会成为潜在的诊断和治疗剂。
