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鳄鱼泪综合征

Crocodile Tears Syndrome

作者信息

Tripathy Koushik, Arsiwalla Tasneem

机构信息

ASG Eye Hospital, BT Road, Kolkata, India

Royal Victorian Eye and Ear hospital

Abstract

The term “crocodile tears” stems from the ancient belief that crocodiles weep after killing their victims. Crocodile tears syndrome, also known as Bogorad syndrome, is a disorder marked by the shedding of tears while eating, chewing, smelling, or drinking in patients recovering from facial nerve (cranial nerve VII) injury. The syndrome is named after F.A. Bogorad, a Russian neuropathologist, and is also referred to as "gustatory lacrimation" or "paroxysmal lacrimation."  Crocodile tears syndrome typically occurs as a sequela of facial nerve injury, often following Bell palsy, surgery, or trauma. Aberrant regeneration of the facial nerve leads to the misdirection of its autonomic fibers toward the lacrimal glands instead of the salivary glands, resulting in lacrimal gland stimulation and tearing during mastication. The diagnosis is clinical and may be confirmed through the Schirmer test combined with gustatory stimulation. Management options include botulinum toxin injections to the lacrimal gland, topical anticholinergics, and surgical interventions such as vidian neurectomy in severe cases. The prognosis is generally favorable, but symptoms may persist, requiring periodic treatment.

摘要

“鳄鱼的眼泪”一词源于古代的一种观念,即鳄鱼在杀死猎物后会哭泣。鳄鱼泪综合征,也称为博戈拉德综合征,是一种在面神经(颅神经VII)损伤恢复过程中的患者中出现的病症,其特征是在进食、咀嚼、闻到气味或饮水时流泪。该综合征以俄罗斯神经病理学家F.A.博戈拉德的名字命名,也被称为“味觉性流泪”或“阵发性流泪”。鳄鱼泪综合征通常作为面神经损伤的后遗症出现,常见于贝尔麻痹、手术或外伤之后。面神经的异常再生导致其自主神经纤维错向泪腺而非唾液腺,从而在咀嚼时刺激泪腺并引起流泪。诊断基于临床症状,可通过结合味觉刺激的施密特试验来确诊。治疗方法包括向泪腺注射肉毒杆菌毒素、局部使用抗胆碱能药物,以及在严重病例中进行手术干预,如岩浅大神经切断术。总体预后良好,但症状可能持续存在,需要定期治疗。

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