Healthy Brain Ageing Program, Brain and Mind Centre, The University of Sydney , Camperdown , New South Wales , Australia.
NeuroSleep, NHMRC Centre of Research Excellence , Sydney.
Behav Sleep Med. 2019 Nov-Dec;17(6):778-789. doi: 10.1080/15402002.2018.1518223. Epub 2018 Sep 24.
: Sleep-wake disturbance is associated with poor cognitive functioning and several other adverse outcomes that increase dementia risk in older adults. Targeting sleep-wake disturbance in individuals at risk for dementia may be an important treatment. This study evaluated the efficacy of a four-session multicomponent group intervention for participants with mild cognitive impairment (MCI). : Thirty-five older adults with MCI (mean age = 69.7 years, = 9.1), were recruited. MCI was determined via consensus from neuropsychological, medical, and neurological review. : Participants were randomized to the "Sleep Well, Think Well" (SWTW) group condition or a passive control group. The SWTW group received four fortnightly face-to-face sessions conducted by an experienced sleep psychologist and neuropsychologist. The control group received written material detailing strategies to improve sleep quality. Both groups received fortnightly coaching phone calls. The primary outcome was subjective sleep quality, measured by the Pittsburgh Sleep Quality Index (PSQI). Secondary outcomes included actigraphy sleep measures, daytime sleepiness, cognitive functioning, and depression severity. : The SWTW intervention was associated with a large and statistically significant improvement in subjective sleep quality (Cohen's d = 0.83, < 0.02). A moderate nonsignificant effect was evident in reducing daytime sleepiness (Cohen's d = 0.70, = .08). No significant effects were found on actigraphy markers, depressive symptoms, or tests of cognitive functioning. : The eight-week SWTW group intervention for MCI significantly improved subjective sleep quality when compared with a passive control condition. The program also had a moderate (nonsignificant) effect on reducing daytime sleepiness.
睡眠-觉醒障碍与认知功能障碍和其他一些不良后果有关，这些后果会增加老年人的痴呆症风险。针对痴呆症高危人群的睡眠-觉醒障碍可能是一种重要的治疗方法。本研究评估了针对轻度认知障碍 (MCI) 患者的四节多成分小组干预的疗效。
招募了 35 名患有 MCI（平均年龄 69.7 岁，SD=9.1）的老年人。MCI 通过神经心理学、医学和神经学审查的共识确定。
参与者被随机分配到“睡得好，想得好”（SWTW）组或被动对照组。SWTW 组接受由经验丰富的睡眠心理学家和神经心理学家进行的四次两周一次的面对面小组干预。对照组收到了详细说明改善睡眠质量策略的书面材料。两组均接受两周一次的教练电话咨询。主要结果是主观睡眠质量，通过匹兹堡睡眠质量指数（PSQI）进行测量。次要结果包括活动记录仪睡眠测量、白天嗜睡、认知功能和抑郁严重程度。
SWTW 干预与主观睡眠质量的显著改善相关（Cohen's d=0.83，<0.02）。在减少白天嗜睡方面也有中等程度的显著效果（Cohen's d=0.70，=0.08）。在活动记录仪标记、抑郁症状或认知功能测试方面没有发现显著效果。
与被动对照组相比，为期八周的针对 MCI 的 SWTW 小组干预明显改善了主观睡眠质量。该方案还对减少白天嗜睡有中等（无统计学意义）的效果。
