T细胞急性淋巴细胞白血病（FAB-L2）中的一种t(9;11)(p11;q23)易位。
A translocation t(9;11)(p11;q23) in T-cell acute lymphoblastic leukemia (FAB-l2).
作者信息
Fan Y S, Rowe J M, Dal Cin P D, Sandberg A A
机构信息
Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, New York.
出版信息
Cancer Genet Cytogenet. 1988 Apr;31(2):263-9. doi: 10.1016/0165-4608(88)90226-9.
We here report a t(9;11)(p11;q23) as the only abnormality in the affected cells of a 20-year-old male with acute lymphoblastic leukemia (L2) of T-cell origin. One hundred six patients with acute leukemia and involvement of band 11q23 were reviewed. Young age, hyperleukocytosis, and poor prognosis characterized almost all the cases in the acute leukemias with the 11q23 translocation, despite involvement of different recipient chromosomes and different morphologic and immunologic phenotypes.
我们在此报告一名20岁男性T细胞起源的急性淋巴细胞白血病（L2）患者，其受累细胞中唯一的异常为t(9;11)(p11;q23)。回顾了106例急性白血病且累及11q23带的患者。尽管涉及不同的受体染色体以及不同的形态学和免疫表型，但几乎所有伴有11q23易位的急性白血病病例均具有年龄小、白细胞增多和预后不良的特征。
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