人类乳腺癌的细胞遗传学分析。II. 使用直接制片法对三倍体/四倍体范围内的7例病例进行研究。

Cytogenetic analysis in human breast carcinoma. II. Seven cases in the triploid/tetraploid range investigated using direct preparations.

作者信息

Hill S M, Rodgers C S, Hultén M A

出版信息

Cancer Genet Cytogenet. 1987 Jan;24(1):45-62. doi: 10.1016/0165-4608(87)90082-3.

Abstract

This report presents karyotypes of seven breast carcinomas with high ploidy from our total of 111 cases. These karyotypes were highly complex and there was no indication of a specific deletion of 16p12----pter as indicated by the previous analysis of some near-diploid tumors. A comparison of numerical changes did not demonstrate a common loss of chromosome #16 as in the near-diploid tumors, but an equivalent loss of chromosomes #8 and #13 was found.

摘要

本报告展示了我们收集的111例乳腺癌病例中7例高倍体乳腺癌的核型。这些核型高度复杂，并且没有迹象表明存在先前在一些近二倍体肿瘤分析中所指出的16p12----pter的特异性缺失。与近二倍体肿瘤相比，数值变化分析并未显示出常见的16号染色体缺失，但发现8号和13号染色体存在同等程度的缺失。