Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.
Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.
PLoS One. 2018 Sep 24;13(9):e0204372. doi: 10.1371/journal.pone.0204372. eCollection 2018.
To date, studies on inflammatory breast cancer (IBC) lack comprehensive epidemiological data. We analyzed detailed prospectively collected clinical and epidemiological data from the IBC Registry at The University of Texas MD Anderson Cancer Center.
Patients with IBC (n = 248) were consecutively diagnosed and prospectively enrolled between November 2006 and April 2013. All patients were newly diagnosed and at least 18 years old. Secondary IBC was excluded. Overall 160 variables were collected and evaluated including sociodemographics, anthropometrics, tobacco and alcohol consumption, reproductive variables, and family history data.
Mean age at diagnosis was 51.6 (±11.5 SD) years, and the majority of patients were White (77.8%). A mean BMI ≥ 25 kg/m2, irrespective of menopausal status, was observed in 80.2% of all patients, with 82.6% of African Americans being obese. Approximately 42.2% of patients were ever smokers, and 91% reported ever being pregnant. A history of breastfeeding was reported in 54% of patients, with significant differences between ethnic groups in favor of White women (P<0.0001). Other reproductive factors such as use of birth control pills & hormone replacement therapy were also more frequently associated with White women compare to other ethnic groups (P < 0.05). In the multivariate Cox proportional hazard analysis, African American or Hispanic ethnicity, not having breastfed, higher clinical stage, and TNBC subtype were associated with shorter survival.
Our data suggest that IBC is associated with distinct epidemiological profiles. This information could assist in targeting patients with specific preventive strategies based on their modifiable behavioral patterns.
迄今为止，有关炎性乳腺癌 (IBC) 的研究缺乏全面的流行病学数据。我们分析了来自德克萨斯大学 MD 安德森癌症中心 IBC 注册处的详细前瞻性收集的临床和流行病学数据。
连续诊断并于 2006 年 11 月至 2013 年 4 月期间前瞻性纳入 248 例 IBC 患者。所有患者均为初诊且年龄至少为 18 岁。排除继发性 IBC。共收集和评估了 160 个变量，包括社会人口统计学、人体测量学、烟草和酒精使用、生殖变量以及家族史数据。
诊断时的平均年龄为 51.6（±11.5 标准差）岁，大多数患者为白人（77.8%）。所有患者中有 80.2%的人存在 BMI≥25kg/m2，不论绝经状态如何，其中 82.6%的非裔美国人肥胖。大约 42.2%的患者曾吸烟，91%的患者报告曾怀孕。有 54%的患者有哺乳史，不同种族组之间存在显著差异，白人女性更常见（P<0.0001）。其他生殖因素，如使用避孕药和激素替代疗法，与白人女性相比，也更常见于其他种族组（P<0.05）。在多变量 Cox 比例风险分析中，非裔美国人或西班牙裔、未哺乳、更高的临床分期和三阴性乳腺癌亚型与较短的生存期相关。
我们的数据表明，IBC 与独特的流行病学特征相关。这些信息可以帮助针对具有特定可改变行为模式的患者制定特定的预防策略。
