Department of Otolaryngology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China.
J Healthc Eng. 2022 Mar 24;2022:2916700. doi: 10.1155/2022/2916700. eCollection 2022.
In this research study, we will study the clinical effect of Biyuan Tongqiao granules with saline nasal irrigation for treatment of chronic sinusitis. It will also study its impacts on the computed tomography (CT) score of the nasal sinus and negative reactions in patients. For this purpose, ninety (90) patients with chronic sinusitis were admitted to the hospital (June 2019 to June 2020). They were selected as the research subjects and divided into experimental and control groups randomly with 45 cases in each group. Control group patients were treated with nasal irrigation with normal saline. While, Biyuan Tongqiao granules combined with nasal irrigation with normal saline was treated by the experimental group. The CT scores of nasal sinus, clinical effect, the incidence of adverse reactions, recurrence rate, duration of nasal mucosal epithelialization, and nasal ciliary transmission speed of both the groups were compared. The patients' pain was assessed by the visual analogue scale (VAS), and the symptoms of sinusitis were scored by the SNOT-20 scale. The experimental group showed significantly lower sinus CT scores and better clinical effects. Adverse reactions were not observed in both the groups' probability ( > 0.05). The experimental group presented a significantly lower recurrence rate, shorter duration of nasal mucosal epithelialization, faster nasal ciliary transmission, and sharply lowers VAS scores and SNOT-20 scores than in the control group ( < 0.05). This proves Biyuan Tongqiao granules and nasal irrigation with normal saline can effectually boost the clinical efficacy and lessen the computed tomography score of nasal sinus in chronic sinusitis patients. It has a worthy clinical application and promotion.
在这项研究中,我们将研究鼻渊通窍颗粒联合生理盐水鼻腔冲洗治疗慢性鼻窦炎的临床疗效。同时,还将研究其对鼻鼻窦 CT 评分和患者不良反应的影响。为此,选取 2019 年 6 月至 2020 年 6 月收治的 90 例慢性鼻窦炎患者作为研究对象,随机分为实验组和对照组,各 45 例。对照组患者采用生理盐水鼻腔冲洗治疗,实验组患者采用鼻渊通窍颗粒联合生理盐水鼻腔冲洗治疗。比较两组患者的鼻鼻窦 CT 评分、临床疗效、不良反应发生率、复发率、鼻腔黏膜上皮化时间、鼻纤毛传输速度,采用视觉模拟评分法(VAS)评估患者疼痛程度,采用 SNOT-20 量表评估鼻窦炎症状。实验组患者的鼻窦 CT 评分明显更低,临床疗效更好,不良反应发生率与对照组比较差异无统计学意义(>0.05)。实验组患者的复发率更低,鼻腔黏膜上皮化时间更短,鼻纤毛传输速度更快,VAS 评分和 SNOT-20 评分更低,差异均有统计学意义(<0.05)。这证明鼻渊通窍颗粒联合生理盐水鼻腔冲洗能有效提高慢性鼻窦炎患者的临床疗效,降低鼻鼻窦 CT 评分,值得临床推广应用。