Biotechnology and Cosmetics Research Center, Sacred Heart Catholic University, Rome, Italy -
Kalibios srl, Eurofins, Rome, Italy.
G Ital Dermatol Venereol. 2019 Jun;154(3):338-341. doi: 10.23736/S0392-0488.18.05986-2. Epub 2018 Sep 20.
Hyperhidrosis is a fairly common condition characterized by excessive sweating, usually in axillary areas. Although not leading to major health problems, it causes significant psychological distress and bears a negative impact on sociality and quality of life in general. The first line of defense used to address this problem are antiperspirants, usually containing aluminum salts, capable of blocking the excessive sweating.
We made a clinical trial to test the deodorant effectiveness and anti-bacterial activity of an antiperspirant product, based on agaricine, aluminum hydrochloride, and silver citrate, in a cohort of 20 subjects following a single laboratory application under controlled conditions. Later, the same product has been tested for skin compatibility, effectiveness and cosmetic quality after repeated home applications under normal conditions of use for 14 consecutive days.
After 6 and 24 hours from the application, the microbial load observed in treated axilla was inferior in a statistically significant way compared to the untreated axilla. Pathogenic bacteria have not been found on any of the two armpits. The tested product has shown an excellent anti-bacterial activity.
Overall, the product has been highly appreciated by the volunteers for its effectiveness and its cosmetic qualities, particularly because it has a good deodorant activity, which persist throughout the day, it does not stain clothes, and it has a practical package.
多汗症是一种相当常见的病症，其特征是过度出汗，通常在腋下区域。虽然不会导致重大健康问题，但它会引起严重的心理困扰，并对社交和整体生活质量产生负面影响。解决这个问题的首要方法是使用止汗剂，通常含有铝盐，能够阻止过度出汗。
我们进行了一项临床试验，以测试一种基于琼脂酸、盐酸铝和柠檬酸银的止汗剂产品在 20 名受试者中的除臭效果和抗菌活性，这些受试者在受控条件下进行了单次实验室应用。之后，我们在正常使用条件下连续 14 天重复家庭应用，测试了相同产品的皮肤相容性、有效性和美容质量。
在应用后 6 小时和 24 小时，与未经处理的腋下相比，处理过的腋下的微生物负荷在统计学上明显较低。两个腋窝都没有发现致病菌。该测试产品表现出优异的抗菌活性。
总的来说，志愿者对该产品的有效性和美容品质给予了高度评价，特别是因为它具有良好的除臭效果，能持续一整天，不会弄脏衣服，而且包装实用。
