新型调节性 Th17 细胞和调节性 B 细胞在调节自身免疫性疾病中的作用。

Novel regulatory Th17 cells and regulatory B cells in modulating autoimmune diseases.

机构信息

Centre for Human Immunology, University of Western Ontario, London, ON, Canada; Department of Microbiology and Immunology, University of Western Ontario, London, ON, Canada; Robarts Research Institute, University of Western Ontario, London, ON, Canada.

Centre for Human Immunology, University of Western Ontario, London, ON, Canada; Department of Microbiology and Immunology, University of Western Ontario, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada.

出版信息

Cell Immunol. 2019 May;339:29-32. doi: 10.1016/j.cellimm.2018.09.002. Epub 2018 Sep 17.

DOI:10.1016/j.cellimm.2018.09.002

PMID:30249342

Abstract

Pathogenic lymphocytes aberrantly recognize and mount an immune response against self-antigens, leading to the destruction of healthy cells, tissues and organs. Recent studies have shown that both B and T lymphocytes contribute to the development, prevention and modulation of various autoimmune diseases. Regulatory T and B cell subsets appear to play a prominent role in the prevention of autoimmune diseases. The recent identification of novel regulatory Th17 cells, termed as Treg17 cells, has expanded the scope of regulatory T lymphocytes (Treg cells) in the prevention of autoimmune diseases. Similarly, novel regulatory B cell subsets, termed as Breg cells, acting on their own or by inducing Treg cells have extended the role of B lymphocytes in the prevention and regulation of autoimmune diseases. We suggest that Treg17 cells and Breg cells have an important immunoregulatory role in autoimmune diseases.

摘要

致病性淋巴细胞异常识别和启动针对自身抗原的免疫反应，导致健康细胞、组织和器官的破坏。最近的研究表明，B 淋巴细胞和 T 淋巴细胞都有助于各种自身免疫性疾病的发生、预防和调节。调节性 T 和 B 细胞亚群似乎在预防自身免疫性疾病中发挥重要作用。最近发现的新型调节性 Th17 细胞，称为 Treg17 细胞，扩展了调节性 T 淋巴细胞（Treg 细胞）在预防自身免疫性疾病中的作用。同样，新型调节性 B 细胞亚群，称为 Breg 细胞，通过自身作用或诱导 Treg 细胞，扩展了 B 淋巴细胞在预防和调节自身免疫性疾病中的作用。我们认为 Treg17 细胞和 Breg 细胞在自身免疫性疾病中具有重要的免疫调节作用。