Moulis Manon, Vindis Cecile
INSERM, UMR-1048, Institute of Cardiovascular and Metabolic Diseases and University Paul Sabatier; F-31342 Toulouse, France.
Cells. 2018 Sep 24;7(10):149. doi: 10.3390/cells7100149.
Autophagy is a highly conserved homeostatic cellular mechanism that mediates the degradation of damaged organelles, protein aggregates, and invading pathogens through a lysosome-dependent pathway. Over the last few years, specific functions of autophagy have been discovered in many tissues and organs; however, abnormal upregulation or downregulation of autophagy has been depicted as an attribute of a variety of pathologic conditions. In this review, we will describe the current knowledge on the role of autophagy, from its regulation to its physiological influence, in metabolic age-related disorders. Finally, we propose to discuss the therapeutic potential of pharmacological and nutritional modulators of autophagy to treat metabolic diseases.
自噬是一种高度保守的细胞稳态机制，通过溶酶体依赖性途径介导受损细胞器、蛋白质聚集体和入侵病原体的降解。在过去几年中，自噬的特定功能已在许多组织和器官中被发现；然而，自噬的异常上调或下调已被描述为多种病理状况的一个特征。在本综述中，我们将描述目前关于自噬在代谢性年龄相关疾病中的作用的知识，从其调节到其生理影响。最后，我们建议讨论自噬的药理学和营养调节剂在治疗代谢性疾病方面的治疗潜力。
