Wang Ning-Ning, Dong Jie, Zhang Lin, Ouyang Defang, Cheng Yan, Chen Alex F, Lu Ai-Ping, Cao Dong-Sheng
Xiangya School of Pharmaceutical Sciences, Central South University, No. 172, Tongzipo Road, Yuelu District, Changsha, People's Republic of China.
Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, Hunan Key Laboratory of Processed Food for Special Medical Purpose, National Engineering Laboratory for Deep Processing of Rice and Byproducts, Central South University of Forestry and Technology, Changsha, People's Republic of China.
J Cheminform. 2018 Jul 31;10(1):34. doi: 10.1186/s13321-018-0289-4.
Autophagy is an important homeostatic cellular recycling mechanism responsible for degrading unnecessary or dysfunctional cellular organelles and proteins in all living cells. In addition to its vital homeostatic role, this degradation pathway also involves in various human disorders, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. Therefore, the comprehensive understanding of autophagy process, autophagy-related modulators and corresponding pathway and disease information will be of great help for identifying the new autophagy modulators, potential drug candidates, new diagnostic and therapeutic targets. In recent years, some autophagy databases providing structural and functional information were developed, but the specific databases covering autophagy modulator (proteins, chemicals and microRNAs)-related target, pathway and disease information do not exist. Hence, we developed an online resource, Human Autophagy Modulator Database (HAMdb, http://hamdb.scbdd.com ), to provide researchers related pathway and disease information as many as possible. HAMdb contains 796 proteins, 841 chemicals and 132 microRNAs. Their specific effects on autophagy, physicochemical information, biological information and disease information were manually collected and compiled. Additionally, lots of external links were available for more information covering extensive biomedical knowledge. HAMdb provides a user-friendly interface to query, search, browse autophagy modulators and their comprehensive related information. HAMdb will help researchers understand the whole autophagy process and provide detailed information about related diseases. Furthermore, it can give hints for the identification of new diagnostic and therapeutic targets and the discovery of new autophagy modulators. In a word, we hope that HAMdb has the potential to promote the autophagy research in pharmacological and pathophysiological area.
自噬是一种重要的细胞内稳态循环机制，负责降解所有活细胞中不必要或功能失调的细胞器和蛋白质。除了其至关重要的内稳态作用外，这种降解途径还涉及多种人类疾病，包括代谢性疾病、神经退行性疾病、癌症和传染病。因此，全面了解自噬过程、自噬相关调节因子以及相应的途径和疾病信息，将有助于识别新的自噬调节因子、潜在的药物候选物、新的诊断和治疗靶点。近年来，一些提供结构和功能信息的自噬数据库得以开发，但涵盖自噬调节因子（蛋白质、化学物质和微小RNA）相关靶点、途径和疾病信息的特定数据库尚不存在。因此，我们开发了一个在线资源——人类自噬调节因子数据库（HAMdb，http://hamdb.scbdd.com ），以尽可能多地为研究人员提供相关途径和疾病信息。HAMdb包含796种蛋白质、841种化学物质和132种微小RNA。我们手动收集并整理了它们对自噬的具体影响、理化信息、生物学信息和疾病信息。此外，还提供了许多外部链接以获取涵盖广泛生物医学知识的更多信息。HAMdb提供了一个用户友好的界面，用于查询、搜索和浏览自噬调节因子及其全面的相关信息。HAMdb将帮助研究人员了解整个自噬过程，并提供有关相关疾病的详细信息。此外，它可以为识别新的诊断和治疗靶点以及发现新的自噬调节因子提供线索。总之，我们希望HAMdb有潜力促进药理学和病理生理学领域的自噬研究。
