Al-Hasani A M, Barton I G, Al-Omer L S, Kinghorn G R, Potter C W
J Antimicrob Chemother. 1986 Oct;18 Suppl B:113-9. doi: 10.1093/jac/18.supplement_b.113.
Virus isolates from 55 patients with recurrent or first-episode genital herpes, treated with various formulation of acyclovir, were tested for their susceptibility to the drug. In all but one of these patients pre-treatment isolates were available for comparison with later isolates. In none of patients, even those receiving long-term prophylaxis, was the susceptibility of the post-treatment isolates significantly reduced.
从55例复发性或初发性生殖器疱疹患者中分离出病毒,这些患者接受了各种剂型的阿昔洛韦治疗,并对分离出的病毒进行了药物敏感性测试。除1例患者外,所有这些患者治疗前的病毒分离株都可用于与后来的分离株进行比较。在所有患者中,即使是接受长期预防治疗的患者,治疗后的分离株敏感性均未显著降低。