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二氧化钛(TiO)纳米粒子在癌症治疗中的应用。

Application of titanium dioxide (TiO) nanoparticles in cancer therapies.

机构信息

a Ege Universitesi Tip Fakultesi , Izmir , Turkey.

出版信息

J Drug Target. 2019 Aug;27(7):762-766. doi: 10.1080/1061186X.2018.1527338. Epub 2018 Oct 15.

DOI:10.1080/1061186X.2018.1527338
PMID:30252540
Abstract

Cancer is one of the most common diseases all over the world; many people suffer from diverse types of cancer. However, currently there is no exact cure or therapy developed for cancer. On the other hand, nanoparticles are defined as microscopic particles that have dimensions less than 100 nm and they are known for their usage in health sciences and medicine, however a few harmful effects on different animal cells. Therefore, researchers began to use nanoparticles for cancer therapies and to develop new methods for much more effective therapies. Nanoparticles in cancer studies are commonly used in photodynamic therapy (PDT) and sonodynamic therapy (SDT) as a sensitising agent, in computed tomography imaging (CT) and radiation therapy as an enhancement agent, in dual-mode image contrast and enhancement therapy as an image contrast agent. Titanium dioxide nanoparticles (TiO NPs) are known as commonly used nanoparticles in medical applications and hence in cancer studies. They are used in PDT, SDT and drug delivery systems. As cancer continues to affect people, new therapeutics and therapies will be developed and nanotechnology for this aim will be an important approach for the researchers.

摘要

癌症是全世界最常见的疾病之一;许多人患有各种类型的癌症。然而,目前还没有针对癌症的确切治疗方法或疗法。另一方面,纳米粒子被定义为尺寸小于 100nm 的微观粒子,它们在健康科学和医学中被广泛应用,但对不同动物细胞也有一些有害影响。因此,研究人员开始将纳米粒子用于癌症治疗,并开发新的方法以实现更有效的治疗。在癌症研究中,纳米粒子通常用作光敏剂用于光动力疗法(PDT)和声动力疗法(SDT),用作增强剂用于计算机断层扫描成像(CT)和放射治疗,用作双模式图像对比和增强治疗的图像对比剂。二氧化钛纳米粒子(TiO NPs)是医学应用中常用的纳米粒子,因此也用于癌症研究。它们用于 PDT、SDT 和药物输送系统。随着癌症继续影响人们,新的治疗方法和疗法将被开发出来,纳米技术将成为研究人员的重要方法。

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