Miami VA, Veterans Affairs Medical Center, Miami, FL, USA.
Miami VA, Veterans Affairs Medical Center, Miami, FL, USA; Division of Population Health and Computational Medicine, USA.
Ocul Surf. 2019 Jan;17(1):64-69. doi: 10.1016/j.jtos.2018.09.002. Epub 2018 Sep 22.
Our aim was to correlate cardiovascular risk factor estimation with bulbar conjunctival blood flow metrics as measured through Functional Slit Lamp Biomicroscopy (FSLB).
Cross-sectional study of individuals with otherwise healthy eyelid and corneal anatomy recruited from the Miami Veterans Affairs (VA) Healthcare System eye clinic. We measured conjunctival microvascular hemodynamics by mounting a camera on a slit lamp and cardiovascular risk using the Framingham risk score. Our main outcome measures were correlations between conjunctival vessel parameters (axial and cross-sectional blood flow velocity, blood flow rate) and Framingham score.
We included 84 patients who underwent FSLB. The mean age was 60 years, the majority were male (88%) and approximately half the patients were black (54%). Mean vessel diameter was similar between all Framingham score categories. Axial and cross-sectional blood flow velocities and blood flow rate were lower in individuals with higher Framingham risk score. Specifically, mean cross-sectional blood flow velocity in individuals with a low Framingham risk score was 0.37 ± 0.0.9 mm/s, with an intermediate score was 0.30 ± 0.09 mm/s, and with a high score was 0.29 ± 0.10 mm/s, p = 0.04. Mean blood flow rate in individuals with a low Framingham risk score was 133.4 ± 59.6 pl/s, with an intermediate score was 123.6 ± 39.3 pl/s, and with a high score was 121.9 ± 52.6 pl/s, p = 0.04. The beta coefficient of the blood flow rate for change in Framingham score was -0.73; 95% CI-1.34-0.13, p = 0.02, adjusted for race.
FSLB correlates with cardiovascular risk estimation. Future studies should evaluate if FSLB can predict cardiovascular outcomes.
我们的目的是通过功能裂隙灯生物显微镜（Functional Slit Lamp Biomicroscopy，FSLB）测量球结膜血流的指标，将心血管风险因素的评估与球结膜联系起来。
这是一项横断面研究，研究对象来自迈阿密退伍军人事务部（VA）医疗系统眼科诊所，这些个体的眼睑和角膜解剖结构均健康。我们通过在裂隙灯上安装摄像头来测量结膜微血管血液动力学，并使用弗雷明汉风险评分来评估心血管风险。我们的主要观察指标是结膜血管参数（轴向和横截面血流速度、血流率）与弗雷明汉评分之间的相关性。
我们纳入了 84 名接受 FSLB 检查的患者。平均年龄为 60 岁，大多数为男性（88%），约一半的患者为黑人（54%）。所有弗雷明汉评分类别之间的平均血管直径相似。轴向和横截面血流速度及血流率在弗雷明汉风险评分较高的个体中较低。具体而言，弗雷明汉风险评分低的个体的平均横截面血流速度为 0.37±0.09mm/s，评分中等的为 0.30±0.09mm/s，评分高的为 0.29±0.10mm/s，p=0.04。弗雷明汉风险评分低的个体的平均血流率为 133.4±59.6pl/s，评分中等的为 123.6±39.3pl/s，评分高的为 121.9±52.6pl/s，p=0.04。血流率随弗雷明汉评分变化的β系数为-0.73；95%CI-1.34-0.13，p=0.02，经种族调整后。
FSLB 与心血管风险评估相关。未来的研究应评估 FSLB 是否可以预测心血管结局。
