Leishmania promastigotes are recognized by the macrophage receptor for advanced glycosylation endproducts.
作者信息
Mosser D M, Vlassara H, Edelson P J, Cerami A
出版信息
J Exp Med. 1987 Jan 1;165(1):140-5. doi: 10.1084/jem.165.1.140.
Abstract
In this paper we demonstrate the involvement of the macrophage receptor for advanced glycosylation endproducts (AGE) in the phagocytosis of Leishmania major promastigotes. Blocking of this receptor with the ligand, AGE-BSA, leads to a 50% decrease in phagocytosis relative to controls, and a comparable decrease in the respiratory burst. The inhibition of phagocytosis by AGE-BSA was specific to leishmania. The binding of zymosan or C3bi-RBC and the phagocytosis of IgG-RBC or latex beads was not affected by the presence of AGE-BSA. Blocking of both the AGE receptor and CR3 decreases leishmania binding by nearly 90%, and reduces the respiratory burst by 80%, indicating that the two receptors account for the bulk of L. tropica promastigote recognition and uptake by the macrophage.
摘要
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本文引用的文献
1
Phagocytosis and killing of the protozoan Leishmania donovani by human polymorphonuclear leukocytes.
J Immunol. 1981 Oct;127(4):1438-43.
2
Nonenzymatic glycosylation of peripheral nerve protein in diabetes mellitus.
Proc Natl Acad Sci U S A. 1981 Aug;78(8):5190-2. doi: 10.1073/pnas.78.8.5190.
3
Accumulation of diabetic rat peripheral nerve myelin by macrophages increases with the presence of advanced glycosylation endproducts.
J Exp Med. 1984 Jul 1;160(1):197-207. doi: 10.1084/jem.160.1.197.
4
Aging of proteins: isolation and identification of a fluorescent chromophore from the reaction of polypeptides with glucose.
Proc Natl Acad Sci U S A. 1984 May;81(9):2684-8. doi: 10.1073/pnas.81.9.2684.
5
Nonenzymatic glycosylation and the pathogenesis of diabetic complications.
Ann Intern Med. 1984 Oct;101(4):527-37. doi: 10.7326/0003-4819-101-4-527.
6
Activation of the alternative complement pathway by Leishmania promastigotes: parasite lysis and attachment to macrophages.
J Immunol. 1984 Mar;132(3):1501-5.
7
Macrophage complement and lectin-like receptors bind Leishmania in the absence of serum.
J Exp Med. 1985 Jul 1;162(1):324-31. doi: 10.1084/jem.162.1.324.
8
The mouse macrophage receptor for C3bi (CR3) is a major mechanism in the phagocytosis of Leishmania promastigotes.
J Immunol. 1985 Oct;135(4):2785-9.
9
A model in mice for experimental leishmaniasis with a West African strain of Leishmania tropica.
Am J Trop Med Hyg. 1979 May;28(3):472-9. doi: 10.4269/ajtmh.1979.28.472.
10
Mac-1: a macrophage differentiation antigen identified by monoclonal antibody.
Eur J Immunol. 1979 Apr;9(4):301-6. doi: 10.1002/eji.1830090410.
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