Costa-da-Silva Ana Caroline, Nascimento Danielle de Oliveira, Ferreira Jesuino R M, Guimarães-Pinto Kamila, Freire-de-Lima Leonardo, Morrot Alexandre, Decote-Ricardo Debora, Filardy Alessandra Almeida, Freire-de-Lima Celio Geraldo
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21944-970, Brazil.
Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica 23890-000, Brazil.
Trop Med Infect Dis. 2022 Mar 31;7(4):54. doi: 10.3390/tropicalmed7040054.
Leishmaniasis is a parasitic, widespread, and neglected disease that affects more than 90 countries in the world. More than 20 species cause different forms of leishmaniasis that range in severity from cutaneous lesions to systemic infection. The diversity of leishmaniasis forms is due to the species of parasite, vector, environmental and social factors, genetic background, nutritional status, as well as immunocompetence of the host. Here, we discuss the role of the immune system, its molecules, and responses in the establishment, development, and outcome of Leishmaniasis, focusing on innate immune cells and interactions.
利什曼病是一种寄生虫病，广泛传播且被忽视，全球有90多个国家受到影响。20多种利什曼原虫会引发不同形式的利什曼病，其严重程度从皮肤损伤到全身感染不等。利什曼病形式的多样性归因于寄生虫种类、传播媒介、环境和社会因素、遗传背景、营养状况以及宿主的免疫能力。在此，我们讨论免疫系统及其分子和反应在利什曼病的发生、发展和转归中的作用，重点关注固有免疫细胞及其相互作用。
